Zur Behandlung von apoplektischen Insulten mit gefäßerweiternden Mitteln

Hangarter, W.; Henssge, J

doi:10.1055/s-0028-1115827

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Olivarius (1970) reported improvement in 67 patients with slight to severe pareses after acute ischemic stroke. Only the study by Geismar (1976) was controlled and the therapeutic value of theophylline in ischemic brain infarction has remained equivocal (Hangarter & Henssge 1956, Hadorn 1960.…”

Section: Discussionmentioning

confidence: 99%

Lack of effect of theophylline on the outcome of acute cerebral infarction

Britton¹,

Fairé²,

Helmers³

et al. 1980

Acta Neurologica Scandinavica

View full text Add to dashboard Cite

In patients with acute ischemic stroke, dramatic but often transient improvements have been noticed after theophylline injections. Whether better results could be obtained by continuous infusion of the drug was evaluated in a double-blind study. Out of 46 patients with a mean age of 75 years, 22 got theophylline as aminophylline (bolus dose of 230 mg followed by 0.5 mg/kg/h) and 24 placebo during 3 days. The groups were comparable in all aspects at the outset of the trial. Serum theophylline concentrations were kept within the therapeutic range recommended for patients with asthma. No significant difference in outcome was noticed between the groups during the hospital period when repeated neurological assessments by two different scores and mortality were compared.

show abstract

Section: Discussionmentioning

confidence: 99%