The influence of aminophylline infusion into the internal carotid artery on cerebral blood flow (CBF) was studied in 12 patients. Six of them were studied using the N
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O saturation technique of Kety and Schmidt, and the other six using the Xenon-133 intra-arterial injection method of Lassen and Ingvar. Intracarotid infusion of aminophylline resulted in a significant decrease of CBF. Previous studies have shown that aminophylline also reduced CBF when injected intravenously. Furthermore, in the present study it was demonstrated that a small dose of aminophylline which was without cerebral vasoconstricting effect when infused intravenously still reduced CBF when infused into the internal carotid artery. Thus aminophylline is a cerebral vasoconstrictor due to a local action on the cerebral vessels.
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