Zur Altersdiagnostik lebender Personen: der Einfluss des sozioökonomischen Status auf die Skelett- und Zahnentwicklung in einer deutschen Studienkohorte

Timme, Maximilian; Karch, André; Shay, Denys; Ottow, Christian; Schmeling, Andreas

doi:10.1007/s00194-020-00444-7

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…Efforts focus on the application of age-appropriate rule-of-law measures. For example, children should be provided with age-appropriate procedures and interventions to prevent harm to them [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Age-dependent decrease in dental pulp cavity volume as a feature for age assessment: a comparative in vitro study using 9.4-T UTE-MRI and CBCT 3D imaging

et al. 2021

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Evaluation of secondary dentin formation is generally suitable for age assessment. We investigated the potential of modern magnetic resonance imaging (MRI) technology to visualize the dental pulp in direct comparison with cone beam computed tomography (CBCT). To this end, we examined 32 extracted human teeth (teeth 11–48 [FDI]) using 9.4-T ultrashort echo time (UTE)-MRI and CBCT (methods). 3D reconstruction was performed via both manual and semi-automatic segmentation (settings) for both methods in two runs by one examiner. Nine teeth were also examined by a second examiner. We evaluated the agreement between examiners, scan methods, and settings. CBCT was able to determine the pulp volume for all teeth. This was not possible for two teeth on MRI due to MRI artifacts. The mean pulp volume estimated by CBCT was consistently higher (~ 43%) with greater variability. With lower variability in its measurements, evaluation of pulp volume using the MRI method exhibited greater sensitivity to differences between settings (p = 0.016) and between examiners (p = 0.009). The interactions of single-rooted teeth and multi-rooted teeth and method or setting were not found to be significant. For examiner agreement, the mean pulp volumes were similar with overlapping measurements (ICC > 0.995). Suitable for use in age assessment is 9.4-T UTE-MRI with good reliability and lower variation than CBCT. For MRI, manual segmentation is necessary due to a more detailed representation of the interior of the pulp cavity. Since determination of pulp volume is expected to be systematically larger using CBCT, method-specific reference values are indispensable for practical age assessment procedures. The results should be verified under in vivo conditions in the future.

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Section: Introductionmentioning

confidence: 99%

Age-dependent decrease in dental pulp cavity volume as a feature for age assessment: a comparative in vitro study using 9.4-T UTE-MRI and CBCT 3D imaging

et al. 2021

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Magnetic resonance imaging of the knee for chronological age estimation—a systematic review

et al. 2023

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Introduction Radiographs of the hand and teeth are frequently used for medical age assessment, as skeletal and dental maturation correlates with chronological age. These methods have been criticized for their lack of precision, and magnetic resonance imaging (MRI) of the knee has been proposed as a more accurate method. The aim of this systematic review is to explore the scientific and statistical evidence for medical age estimation based on skeletal maturation as assessed by MRI of the knee. Materials and methods A systematic review was conducted that included studies published before April 2021 on living individuals between 8 and 30 years old, with presumptively healthy knees for whom the ossification stages had been evaluated using MRI. The correlation between “mature knee” and chronological age and the risk of misclassifying a child as an adult and vice versa was calculated. Results We found a considerable heterogeneity in the published studies —in terms of study population, MRI protocols, and grading systems used. There is a wide variation in the correlation between maturation stage and chronological age. Conclusion Data from published literature is deemed too heterogenous to support the use of MRI of the knee for chronological age determination. Further, it is not possible to assess the sensitivity, specificity, negative predictive value, or positive predictive value for the ability of MRI to determine whether a person is over or under 18 years old. Key Points • There is an insufficient scientific basis for the use of magnetic resonance imaging of the knee in age determination by skeleton. • It is not possible to assess the predictive value of MRI of the knee to determine whether a person is over or under 18 years of age.

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Preliminary study on genetic factors related to Demirjian’s tooth age estimation method based on genome-wide association analysis

et al. 2023

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Zur Altersdiagnostik lebender Personen: der Einfluss des sozioökonomischen Status auf die Skelett- und Zahnentwicklung in einer deutschen Studienkohorte

Cited by 4 publications

References 27 publications

Age-dependent decrease in dental pulp cavity volume as a feature for age assessment: a comparative in vitro study using 9.4-T UTE-MRI and CBCT 3D imaging

Age-dependent decrease in dental pulp cavity volume as a feature for age assessment: a comparative in vitro study using 9.4-T UTE-MRI and CBCT 3D imaging

Magnetic resonance imaging of the knee for chronological age estimation—a systematic review

Preliminary study on genetic factors related to Demirjian’s tooth age estimation method based on genome-wide association analysis

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