Zunahme des hepatozellulären und des intrahepatischen cholangiozellulären Karzinoms im Nordosten Deutschlands

Schurr, R; Stölzel, Ulrich; Schuppan, D; Schwertner, C.; Steinberg, Johannes; Scherübl, Hans

doi:10.1055/s-2006-947811

Cited by 9 publications

(1 citation statement)

References 35 publications

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“…The incidence is dramatically rising also in Europe [4]. The age-adjusted incidence of HCC in Germany was 5.2 in men in 2002 with a 5-year survival rate of less than 10% [5]. HCC predominantly develops in the context of chronic inflammation [6] and in the setting of cirrhotic livers, but may occur in the absence of cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Time Trends in Etiology of Hepatocellular Cancer in Germany

et al. 2013

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Introduction: The incidence of hepatocellular cancer (HCC) continues to rise in Europe with a shift of the primary cause towards alcoholic and non-alcoholic fatty liver disease. Metabolic factors like diabetes mellitus and overweight have been identified as significant risk factors for HCC development. Patients and Methods: A retrospective analysis in a large single-center cohort of 650 patients diagnosed with HCC was performed. Demographic characteristics, risk factors, tumor stage at diagnosis and survival were evaluated. Results: Among 650 patients (aged 17-87 years, with a male: female ratio of 4:1), 80.8% had underlying liver cirrhosis. Alcohol abuse was identified as the only risk factor for liver cirrhosis in 52.2% of patients. Viral infection with hepatitis C and hepatitis B was present in 13.7 and 3.6% of patients, respectively. 66.1% of patients with HCC were overweight with a body mass index exceeding 25, 25.5% even exceeding 30; 52% of patients had diabetes mellitus. Conclusion: Strategies aiming at prevention and surveillance of patients at risk to develop HCC in the future need to widen the focus from patients with chronic viral hepatitis and a history of alcohol abuse to patients with metabolic risk factors.

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Section: Introductionmentioning

confidence: 99%