Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum

A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition

“…It is now generally accepted that primary liver cancer forms a continuous spectrum from HCC and CC, mimicking each other's morphological and phenotypic properties 24. In the present study, we have shown that a variant of HCCs with scirrhous components (i.e., S‐HCC) has an intermediate phenotype, expressing both CC‐like and stem‐cell‐like traits.…”