Zunahme des hepatozellulären und des intrahepatischen cholangiozellulären Karzinoms im Nordosten Deutschlands

Schurr, R; Stölzel, Ulrich; Schwertner, C.; Steinberg, Johannes; Schuppan, Detlef; Scherübl, Hans

doi:10.1055/s-2006-950950

Cited by 2 publications

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“…In the United States, the incidence has doubled over the past 20 years [1]. A similar trend has been observed in Germany [2], with currently around 6,000 new male and 2,500 new female patients per year ( fig. 1).…”

Section: Introductionsupporting

confidence: 66%

Diagnostics and Treatment of Hepatocellular Carcinoma in 2016: Standards and Developments

2016

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Background: Hepatocellular carcinoma (HCC) is a frequent complication of liver cirrhosis. Worldwide, HCC is one of the most common cancers, with a rising incidence. Methods: A selective literature search was conducted, taking into account current studies, reviews, meta-analyses, and guidelines. Results: The diagnosis is established either non-invasively by dynamic imaging, showing a typical contrast enhancement and wash-out, or histopathologically. Pathological diagnosis of HCC is recommended for all atypical nodules in patients with cirrhosis and for those in non-cirrhotic patients. Tumor therapy as well as treatment of the underlying chronic liver disease and/or preservation of liver function are important for the management of patients with HCC. Standard stage-adapted treatments are based on the widely applied Barcelona Clinic Liver Cancer staging system including liver resection and transplantation, interventional treatments such as thermal ablation and transarterial therapies, and systemic treatment with the tyrosine kinase inhibitor sorafenib. After failure of sorafenib, anti-angiogenic drugs, MET inhibitors, and immunotherapeutics are currently under advanced clinical investigation. Conclusion: Treatment of HCC is multidisciplinary and therefore requires a close cooperation between various disciplines such as hepatology, visceral surgery, radiology, and oncology to achieve the best outcome depending on the tumor stage and degree of liver function impairment.

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Section: Introductionsupporting

confidence: 66%

Diagnostics and Treatment of Hepatocellular Carcinoma in 2016: Standards and Developments

2016

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“…Auch in Deutschland weisen die primären Leberkarzinome steigende Inzidenzen auf [1]. Die wichtigsten Ursachen in den westlichen Ländern sind die hohen bzw.…”

Section: Tumordiagn U Ther 2012; 33unclassified

Übersicht – Therapie des hepatozellulären Karzinoms

Eick¹,

Steinberg²,

Schwertner³

et al. 2012

TumorDiagn u Ther

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Zunahme des hepatozellulären und des intrahepatischen cholangiozellulären Karzinoms im Nordosten Deutschlands

Cited by 2 publications

References 0 publications

Diagnostics and Treatment of Hepatocellular Carcinoma in 2016: Standards and Developments

Diagnostics and Treatment of Hepatocellular Carcinoma in 2016: Standards and Developments

Übersicht – Therapie des hepatozellulären Karzinoms

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