Zum Verhalten der Neurofibrillen unter pathologischen Bedingungen

Bickel, Heinrich

doi:10.1007/bf02322884

Cited by 3 publications

(2 citation statements)

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“…Recent investigation of the neurone has been largely along four lines, viz. (1) to ascertain the method of interneuronal connection;…”

Section: Yale University Medical Schoolmentioning

confidence: 99%

“…They found the endocellular fibrils more attenuated than the extracellular and that the change was more marked in the small pyramidal and polymorphic cells than in the giant pyramidals and was more extensive in the region of the axone hillock and the nucleus, finally terminating in a fragmentation and complete disappearance of the fibrils. Bickel (1) has found that the neurofibrils in the cell body degenerate before those of the processes and those most remote from the cell body are most resistant.…”

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Recent contributions to our knowledge of the neurone.

Ferris¹

1913

Psychological Bulletin

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Reviews recent contributions in the field of neuropsychology. The investigations have been along the following 4 lines: (1) to ascertain the method of interneuronal connection (2) to determine the relations of the neuroglia to the cell body and axones (3) to determine the actual morphologic entities in the cell body and axone and (4) to determine the morphogenesis of the neurone and its various structures. It was found that glia in no instance separates the nerve elements, but in all cases presses into the myelin sheath and forms a supporting myelinic skeleton. Work was carried out on the structure of the axone which may lead to a revision of the existing conception. All the investigators studying morphogenesis agree that Nissl's bodies are developed later in embryonic life, than the neurofibrils. Evidence shows that the axones in vitro and in the body, are developed from the cell bodies as a genetic center.

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“…Recent investigation of the neurone has been largely along four lines, viz. (1) to ascertain the method of interneuronal connection;…”

Section: Yale University Medical Schoolmentioning

confidence: 99%

mentioning

confidence: 99%

Recent contributions to our knowledge of the neurone.

Ferris¹

1913

Psychological Bulletin

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Beitrag zur Kenntnis der Fischerschen Plaques im Gehirn und ihrer klinischen Bedeutung

Schröder¹

1911

Z. f. d. g. Neur. u. Psych.

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Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity

Arendt

2003

Progress in Neurobiology

177

139

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Mental actions are based on the dynamic organization of neuronal networks. In particular, phylogenetically young brain areas (e.g., cortical associative circuits) involved in the realization of higher brain functions are continuously re-adjusted to meet environmental demands. The mechanisms of synaptic plasticity, i.e., of structural stabilization and labilization underlying a life-long synaptic remodelling, are largely based on external morphoregulatory cues and internal signalling pathways that non-neuronal cells have phylogenetically acquired to sense their relationship to the local neighbourhood and to control after development is completed proliferation and differentiation in the process of tissue repair and regeneration. After having withdrawn from the cell cycle, differentiated neurons are, thus, able to use molecular mechanisms primarily developed to control proliferation alternatively to control synaptic plasticity. The existence of these alternative effector pathways within a neuron puts it at risk to erroneously convert signals derived from plastic synaptic changes into positional cues that will activate the cell cycle. This cell cycle activation potentially links synaptic plasticity to cell death. Preventing cell cycle activation by locking neurons in a differentiated but still highly plastic phenotype will, thus, be crucial to prevent neurodegeneration.

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Zum Verhalten der Neurofibrillen unter pathologischen Bedingungen

Cited by 3 publications

References 3 publications

Recent contributions to our knowledge of the neurone.

Recent contributions to our knowledge of the neurone.

Beitrag zur Kenntnis der Fischerschen Plaques im Gehirn und ihrer klinischen Bedeutung

Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity

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