Zum Fluoreszenznachweis von Oxazepam und Lorazepam mit Phthalaldehyd und Analoga

Abstract

On the Fluorescence Detection of Oxazepam and Lorazepam with Phthalaldehyde and AnaloguesRefluxing Oxazepam (1) and Lorazepan1 (2). resp., with ethanolic NaOH, followed by acid hydrolysis affords the 1.3-diamines 5 and 6. Cyclccondensation with phthalaldehyde (11s) and analogues llb-leads to fluorescent compounds of type 14 and 16. On the basis of these investigations a high specific TLC-fluorescence detection of Oxazepam (1)

o-Acylbenzaldehydes in organic synthesis: a brief review

“…6,7,27 They have been also used for a high specific TLC-fluorescent detection of oxazepam and lorazepam. 27 o-Acylbenzaldehydes have also proven to be useful precursors to isoindoles, [2][3][4][5][6] phthalimidines, 19 isoindoloquinazolines, 18 naphthols, 24 indane derivatives, 26 and olefins. 36 Recently, o-acetylbenzaldehyde has been used to synthesize glycosylporphyrins appropriate for cancer photochemotherapy.…”

Synthesis of 6-Phenyl Substituted 2-Formylnicotinates

“…Several methods are known for the generation of an aldehyde group in position 2 of a pyridine; most commonly used is the oxidation of the activated methyl group of 2picolines. 7,8 A new, but multistep procedure is the N-oxidation of 2-methylpyridine and subsequent Boekelheide rearrangement in boiling acetic anhydride giving the 2-acetoxymethylpyridine, which is converted by a second oxidation-rearrangement process to yield 2-(diacetoxymethyl)pyridine as a derivative of pyridine-2carbaldehyde. 9,10 A further new transformation starts with the condensation of 2-methyl-3-nitropyridine with N,Ndimethylformamide dimethylacetal (DMFDMA) yielding an enamine, which is cleaved by treatment with NaIO 4 or ozone to give 3-nitropyridine-2-carbaldehyde.…”