A versatile synthesis of 2-formylnicotinates 6 (R' = Me) and 7 (R' = Et) is described. 6-Phenyl substituted 2-diethoxymethylnicotinates 14/15 are prepared first starting by cyclocondensation of 3-amino-4,4-diethoxybut-2-enoates 12/13 with Mannich base hydrochlorides 1 or ß-aminovinyl ketones 16. Subsequent hydrolysis of the acetal function in 14/15 gives rise to the title compounds.
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