Zum Einfluss einer variierten Vitamin-B₆-Versorgung auf den Vitamin-B₆- Status in Feten und Reproduktionsorganen

Abstract

In order to study the influence of varying vitamin B₆ intake levels on the reproductive performance and the vitamin B₆ status of fetuses and reproductive organs, 30 pregnant rats (Sprague Dawley strain) were fed a semisynthetic casein diet supplemented with 1,6, 12, 24 and 48 mg vitamin B₆/kg throughout pregnancy. On days 19 of pregnancy the rats were killed. Fetuses, placenta, amniotic fluid, amnion, uterus and mammary gland were analysed microbiologically for their vitamin B6 content. Reproductive performance was not influenced by the dietary treatment. Vitamin B₆ concentrations in fetuses, placenta and amniotic fluid of mothers treated with the low 1-ppm vitamin B₆ diet were significantly decreased. At a vitamin B₆ supply of 6 ppm, however, tissue saturation was already reached in these organs. Accordingly, the whole vitamin B₆ retention in the reproductive product plateaued at an intake level of 6 ppm vitamin B₆ at 37 µg vitamin B₆per animal. These results indicate therefore that a level of 6 ppm dietary vitamin B₆is sufficient to guarantee an optimum vitamin B₆ status in the reproductive product, and higher vitamin B₆ supplementations showed no further effect on the parameters investigated.