Zum Einfluß der Glucose auf die Lipidmobilisation aus subcutanem menschlichem Fettgewebe in vitro

Effects of norepinephrine, theophylline and dibutyryl cyclic amp onin vitro lipolysis of human adipose tissue in obesity

“…A described earlier (Thamer et al, 1969), addition of 5.55 mM glucose to the incubation medium resulted in an increment in glycerol release and inhibition of FFA release; yet the relations between lipolysis and cell size were, in general, unaltered (Fig. 4b).…”

“…It has been suggested that this may be due to a higher basal activity of adenyl cyclase (Goldrick and MeLoughlin, 1970). According to cyril findings (Thamer et al, 1969) and in accordance with He (1970) basal lipolysis is regulated by the energy supply of the lipocyte. However, in the present investigations, the relation of the stimulation factor to the cell diameter was not significantly influenced by glucose.…”

“…Investigations performed on obese mice have shown that lipogenesis and lipid mobifisation of the fat cell are apparently related to these morphological changes (Mayer, 1965;Herberg et al, 1970). Investigations in vitro of catecholamine-induced lipolysis of human adipose tissue in obesity resulted in contradictory observations and interpretations (Mosinger et al, 1965;BjSrntorp and Hood, 1966;Preiss et al, 1967;Thamer, 1969;Faulhaber et al, 1969;Goldrick and McLoughlin, 1970), the greater part of which can be explained by the differences in reference systems.…”