Zoster sine herpete with bilateral ocular involvement

Nakamura, Makoto; Tanabe, Masumi; Yamada, Yuko; Azumi, Atsushi

doi:10.1016/s0002-9394(00)00404-9

Cited by 25 publications

(17 citation statements)

References 5 publications

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“…Iris atrophy is a diagnostic feature of viral iridocyclitis that may be caused by HSV, VZV, or CMV [6][7][8][9][10]. Although two of our patients had a history of labial herpes, and patchy depigmentation of the iris in these cases resembled the lesions seen in herpetic iridocyclitis, symmetrical bilateral involvement, lack of intraocular inflammation, and marked pigment dispersion were the differentiating features.…”

Section: Discussionmentioning

confidence: 59%

Bilateral acute depigmentation of the iris

Tuğal-Tutkun

Urgancioğlu

2005

Graefe's Arch Clin Exp Ophthalmo

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In contrast to pigment dispersion syndrome, pigment seemed to be released from iris stroma in the five cases described here. Although patchy depigmentation of the iris resembled the lesions seen in herpetic iridocyclitis in two of the patients, symmetrical bilateral involvement and lack of intraocular inflammation were the differentiating features. The patients described here could represent a new entity or an unusual presentation of herpetic eye disease.

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Section: Discussionmentioning

confidence: 59%

Bilateral acute depigmentation of the iris

Tuğal-Tutkun

Urgancioğlu

2005

Graefe's Arch Clin Exp Ophthalmo

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“…Herpetic anterior uveitis with or without corneal involvement has long been recognized as a distinct clinical entity, and molecular techniques have been recently used to identify the causative agents, including herpes simplex virus (HSV), varicella zoster virus (VZV), and cytomegalovirus (CMV) [2][3][4][5][6][7][8]. Active viral replication and immunologic responses may both play a role in the pathogenesis of herpetic anterior uveitis [9,10].…”

Section: Introductionmentioning

confidence: 99%

Clinical features and prognosis of herpetic anterior uveitis: a retrospective study of 111 cases

2010

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To describe the clinical features and outcomes in patients with herpetic anterior uveitis. We reviewed the records of 111 patients with a clinical diagnosis of herpetic anterior uveitis seen at the Department of Ophthalmology, Istanbul Faculty of Medicine, from January 1996 to December 2006. Demographic and clinical features, recurrence rate, and visual outcome were analyzed. Fifty patients were male, 61 were female. Mean age at presentation was 39.2 ± 16.5 (6-74) years. Three atopic patients had bilateral involvement. Twelve patients had active or a past episode of herpes zoster ophthalmicus. Ocular findings were granulamatous anterior uveitis (93%), active keratitis or corneal scars (57%), elevated intraocular pressure (51%), iris atrophy (48%), distorted pupil (25%), and posterior synechiae (26%). Secondary glaucoma developed in two patients. None of the patients had posterior segment complications. The recurrence rate was 0.45/person-year. Topical corticosteroids and oral antiviral therapy were administered to all patients during active episodes. Long-term prophylactic oral acyclovir was used in 13%. Final visual acuity was worse than 0.5 in 17% of the involved eyes and was due to corneal scarring or cataract formation. Patients with iridocyclitis only had no permanent visual loss. Herpetic anterior uveitis is a recurrent granulomatous disease commonly associated with corneal involvement, iris atrophy, and transient intraocular pressure rise. Visual prognosis is good, especially in patients who have only anterior uveitis without corneal disease.

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“…The third step consists of the elongation step (Elongation) in which Taq polymerase (or another DNA polymerase) has its optimum activity temperature at around 72°C. The last step is the final elongation: the amplified target can be obtained after [30][31][32][33][34][35][36][37][38][39][40] However, multiplex PCR or any other qualitative PCR techniques cannot quantitatively measure copy number of genomic DNA. Given the extremely high sensitivity of PCR, positive results from qualitative PCR techniques can be false positives due to contamination.…”

Section: Multiplex Pcr and Real-time Pcrmentioning

confidence: 99%

“…Genomic DNA of HSV [24][25][26][27], VZV [25,[28][29][30][31], and CMV [6,7,25,[32][33][34][35][36][37][38] has been detected by PCR in the aqueous humor of certain types of AU, corneal endotheliitis, and posterior uveitis with necrotizing retinitis (ARN and CMV retinitis).…”

Section: Hsv1 Hsv2 Vzv and CMVmentioning

confidence: 99%

A new era of uveitis: impact of polymerase chain reaction in intraocular inflammatory diseases

et al. 2016

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Uveitis is a sight-threatening intraocular inflammatory disorder which may occur from both infectious and non-infectious or autoimmune causes. The frequency of infectious uveitis and autoimmune uveitis varies depending on countries and regions. According to a nationwide survey conducted by the Japanese Ocular Inflammation Society, infectious and non-infectious uveitis accounted for 16.4 and 50.1% of new patients, respectively while the remaining 33.5% of new uveitis cases were not classified or were idiopathic uveitis. Infectious uveitis is particularly important because it causes tissue damage to the eye and may result in blindness unless treated. However, it can be treated if the pathogenic microorganisms are identified promptly and accurately. Remarkable advancements in molecular and immunological technologies have been made in the last decade, and the diagnosis of infectious uveitis has been greatly improved by the application of molecular and immunological investigations, particularly polymerase chain reaction (PCR). PCR performed on a small amount of ocular samples provides a prompt, sensitive, and specific molecular diagnosis of pathogenic microorganisms in the eye. This technology has opened a new era in the diagnosis and treatment of uveitis, enabling physicians to establish new clinical entities of uveitis caused by infectious microorganisms, identify pathogens in the eyes of many patients with uveitis, and determine prompt diagnosis and appropriate therapy. Here we review the PCR process, new PCR tests specialized for ocular diseases, microorganisms detected by the PCR tests, diseases in the eye caused by these microorganisms, and the clinical characteristics, diagnosis, and therapy of uveitis.

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Zoster sine herpete with bilateral ocular involvement

Cited by 25 publications

References 5 publications

Bilateral acute depigmentation of the iris

Bilateral acute depigmentation of the iris

Clinical features and prognosis of herpetic anterior uveitis: a retrospective study of 111 cases

A new era of uveitis: impact of polymerase chain reaction in intraocular inflammatory diseases

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