1964
DOI: 10.1001/archneur.1964.00460200051005
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Zoster Encephalomyelitis

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Cited by 77 publications
(23 citation statements)
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“…As relentless ascending progression of zoster myeli tis ending in death has been reported in a number of cases [5,6], antiviral therapy might be necessary to halt the progression [7,16]. Our patient received an antivi ral agent, acyclovir, and his neurological symptoms did not show any further progression for 1 month during hospital stay.…”
Section: Discussionmentioning
confidence: 68%
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“…As relentless ascending progression of zoster myeli tis ending in death has been reported in a number of cases [5,6], antiviral therapy might be necessary to halt the progression [7,16]. Our patient received an antivi ral agent, acyclovir, and his neurological symptoms did not show any further progression for 1 month during hospital stay.…”
Section: Discussionmentioning
confidence: 68%
“…The incidence and severity of HZ is greatly increased in persons with defective cel lular immunity such as advancing age, lymphoproliféra tive malignancies and immunosuppressive treatment [8], In these circumstances, dissemination and serious complications of HZ are also more frequent [8,9], How ever, our patient had no evidence of underlying malig nancy and was younger than the other patients with HZ myelitis reported in the literature [5][6][7], It is likely that the clinical manifestations of HZ infection are deter mined by a complex interplay of host-defense defects, activation of latent agents and environmental exposure The pathogenesis of HZ myelitis has been thought as a direct viral invasion because inclusion bodies and VZV particles were found in glial cells, and the virus was iso lated from the spinal cord of patients with zoster myelitis [5], Isolation of the VZV from the CSF or demonstration of the VZV antigen in CSF cells by immunofluorescence is a confirmative evidence for viral central nervous sys tem (CNS) infection but it is rarely successful [ 10,11], Therefore, the diagnosis is usually made on the clinical ground when characteristic CNS symptoms develop in the context of HZ. The association was clear in our case because the interval between the exanthem and the onset of neurologic symptoms was as short as 3 days.…”
Section: Discussionmentioning
confidence: 92%
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“…An early study by Rose et al 10 in 1964 reviewed 40 patients with diffuse meningoencephalitis secondary to VZV. Cases autopsied demonstrated infiltration of the vascular intima and adventitia with giant and mononuclear cells, in both the brain and spinal cord.…”
Section: Discussionmentioning
confidence: 99%