2022
DOI: 10.5455/jabet.2022.d114
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Zoo-chemical profiling, in vivo toxicity, and in vitro anti-inflammatory properties of Luffariella herdmani marine sponge extract

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Cited by 3 publications
(6 citation statements)
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“…The crude extract of L. herdmani that was previously determined as being toxic to A. salina larvae had an LC 50 value of 14.34 μg/ml. 28 Overall, the current study further confirms the extract’s potent toxic nature. The EC 50 value can also be used to select the range of test concentrations for genotoxicity analysis.…”
Section: Resultssupporting
confidence: 75%
See 1 more Smart Citation
“…The crude extract of L. herdmani that was previously determined as being toxic to A. salina larvae had an LC 50 value of 14.34 μg/ml. 28 Overall, the current study further confirms the extract’s potent toxic nature. The EC 50 value can also be used to select the range of test concentrations for genotoxicity analysis.…”
Section: Resultssupporting
confidence: 75%
“…L. herdmani crude extract was previously shown by the authors to exert toxic effects against the brine shrimp Artemia salina . 28…”
Section: Resultsmentioning
confidence: 99%
“…In recent decades, marine pharmacology has received great attention, resulting in a plethora of bioactive compounds with numerous therapeutic properties (Kuruppuarachchi & Gunathilake, 2022). Among all marine invertebrates, sponges are recognised as one of the richest sources of bioactive compounds, accounting for approximately 30% of all marine natural products (Mehbub et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Thus, the toxicity evaluation of sponge crude extracts prior developing into therapeutic products with fewer side effects is crucial. The use of low-cost, reproducible, shortterm biological models that are alternatives to higher animal models are highly recommended in the preliminary drug discovery process (Kuruppuarachchi & Gunathilake, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…Kuruppuarachchi et al used established assays, based on growth and the evaluation of mitotic indices and chromosomal aberration, for Allium cepa (onion) root tip, to assess potential cytotoxicity and genotoxicity of marine sponge extracts. 4 For many years, extracts from marine sponges have been the subject of investigation due to their potential antibacterial, antiviral, antifungal, antimalarial or anticancer effects. The experiments reported here, showed that both cytotoxicity and genotoxicity were induced in the root tips by the extracts.…”
mentioning
confidence: 99%