2023
DOI: 10.1177/02611929231171943
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Use of the Allium cepa Model to Assess the Cytogenotoxicity of Luffariella herdmani Marine Sponge Extract

Abstract: Marine sponge extracts are known to contain potentially toxic compounds that have biological activities of possible pharmacological interest. Thus, it is vital that biological models are used for the preliminary toxicity screening of such extracts. The present study reports the use of Allium cepa, a low-cost plant-based in vivo model, to assess the cytotoxicity and genotoxicity of Luffariella herdmani marine sponge crude extract (SCE). Pre-germinated onion bulbs, exposed for 96 hours to different concentration… Show more

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Cited by 3 publications
(1 citation statement)
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“…Jayathilake and Jayewardena (2021) investigated with the Allium test aqueous extracts from the sea cucumber, Bohadschia vitiensis, known for certain biological activities and found reduced genotoxic effects consisting of 0.1-0.2% chromosomal aberrations including chromosomal bridges, c-mitosis, chromosomal breaks, and vagrants. By using the Allium bioassay, the mitodepressive effect of the marine sponge extracts Luffariella herdmani was highlighted, the results obtained suggesting the antitumor potential of the substances contained (Kuruppuarachchi et al 2023).…”
Section: Discussionmentioning
confidence: 99%
“…Jayathilake and Jayewardena (2021) investigated with the Allium test aqueous extracts from the sea cucumber, Bohadschia vitiensis, known for certain biological activities and found reduced genotoxic effects consisting of 0.1-0.2% chromosomal aberrations including chromosomal bridges, c-mitosis, chromosomal breaks, and vagrants. By using the Allium bioassay, the mitodepressive effect of the marine sponge extracts Luffariella herdmani was highlighted, the results obtained suggesting the antitumor potential of the substances contained (Kuruppuarachchi et al 2023).…”
Section: Discussionmentioning
confidence: 99%