Zoledronic acid conjugated calcium phosphate nanoparticles for applications in cancer immunotherapy

Preparation and application of calcium phosphate nanocarriers in drug delivery

“…As shown in Fig. 3 , the functional groups contain the phosphate group (-PO 3 H, nucleic acids, such as DNA, siRNA and microRNA or other small molecule compound, such as zoledronic acid [ 120 ]), the carboxyl group (-COOH, such as naproxen [ 121 ]), the sulfonic group (-SO 3 H, such as methazolamide [ 122 ]), the amino-group (-NH n , such as cisplatin [ 123 ]), the hydroxyl or fluorine group (-OH or –F, such as gemcitabine [ 68 ] and doxorubicin [ 59 ]), the sulfhydryl group (-SH) and so on. Theoretically, small molecule chemical drugs or macromolecular biological drugs containing the functional groups mentioned above may be delivered by the calcium phosphate nanocarriers for various medical applications.…”

“…First, the PAS/Ca 2+ and PDADMAC/PO 4 3− complexes form through electrostatic interactions and then two complexes self-assemble into CaP-HNPs after mixing them together, which can regulate the growth of CaP and reduce the size to the nanometer range. Additionally, arginine [ 76 ], sodium polymethacrylate [ 123 ] and trisodium citrate [ 120 ] were employed as stabilizing agent to constructure nano-CaP for the delivery of siRNA, cisplatin and zoledronic acid or other drugs, respectively.…”