Preparation and application of calcium phosphate nanocarriers in drug delivery

Qiu, Chong; Wu, Yanyan; Guo, Qiuyan; Shi, Qiaoli; Zhang, Junzhe; Meng, Yuqing; Xia, Fei; Wang, Jigang

doi:10.1016/j.mtbio.2022.100501

Cited by 18 publications

(13 citation statements)

References 180 publications

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“…Advanced OA is characterized by more severe symptoms with synovial inflammation, cartilage degeneration or destruction, and subchondral bone remodeling. Accompanied by microenvironment disorder, only a few endogenous MSCs can be found in the cartilage damaged areas, 30 which might be depleted or restricted in recruitment and migration to injured site, preventing MSCs from differentiating into chondrocytes for cartilage repair. Although the differentiation efficiency of endogenous stem cells could be improved by AHK-CaP/siCA9 NPs in early stage OA, the number of endogenous stem cells is far insufficient, and their activity is inhibited in advanced OA.…”

Section: Resultsmentioning

confidence: 99%

“…The AHK-CaP/siRNA NPs were prepared as described in our previous studies. ,, In brief, a solution A was prepared by mixing 20 μL of siRNA (6 μM), 20 μL of AHK (1 μM) and 60 μL of HBS (50 mM HEPES, 280 mM NaCl, 1.5 mM Na 2 HPO 4 , pH = 8.0). This solution A was then slowly added dropwise into solution B (20 μL of CaCl 2 (200 mM)) under ultrasonication at 30 °C.…”

Section: Methodsmentioning

confidence: 99%

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Nanomedicines Promote Cartilage Regeneration in Osteoarthritis by Synergistically Enhancing Chondrogenesis of Mesenchymal Stem Cells and Regulating Inflammatory Environment

Cui,

Yan,

et al. 2024

ACS Nano

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Osteoarthritis (OA) is a degenerative joint disease characterized by progressive erosion of the articular cartilage and inflammation. Mesenchymal stem cells' (MSCs) transplantation in OA treatment is emerging, but its clinical application is still limited by the low efficiency in oriented differentiation. In our study, to improve the therapeutic efficiencies of MSCs in OA treatment by carbonic anhydrase IX (CA9) siRNA (siCA9)-based inflammation regulation and Kartogenin (KGN)-based chondrogenic differentiation, the combination strategy of MSCs and the nanomedicine codelivering KGN and siCA9 (AHK-CaP/siCA9 NPs) was used. In vitro results demonstrated that these NPs could improve the inflammatory microenvironment through repolarization of M1 macrophages to the M2 phenotype by downregulating the expression levels of CA9 mRNA. Meanwhile, these NPs could also enhance the chondrogenesis of bone marrow-derived mesenchymal stem cells (BMSCs) by upregulating the pro-chondrogenic TGF-β1, ACAN, and Col2α1 mRNA levels. Moreover, in an advanced OA mouse model, compared with BMSCs alone group, the lower synovitis score and OARSI score were found in the group of BMSCs plus AHK-CaP/siCA9 NPs, suggesting that this combination approach could effectively inhibit synovitis and promote cartilage regeneration in OA progression. Therefore, the synchronization of regulating the inflammatory microenvironment through macrophage reprogramming (CA9 gene silencing) and promoting MSCs oriented differentiation through a chondrogenic agent (KGN) may be a potential strategy to maximize the therapeutic efficiency of MSCs for OA treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Nanomedicines Promote Cartilage Regeneration in Osteoarthritis by Synergistically Enhancing Chondrogenesis of Mesenchymal Stem Cells and Regulating Inflammatory Environment

Cui,

Yan,

et al. 2024

ACS Nano

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“…For drug delivery, it fulfills many important requirements for efficient delivery systems, namely, the ability to incorporate drugs or biomolecules on physically or covalently bound internal and external surfaces and the ability to retain such biomolecules until the particles reach the target site and dissolve, as well as its inherent biodegradability (calcium and phosphate ions). 112,113 114 To optimize the potential of HAp, trace elements such as zinc, iron, potassium, and sodium can be mixed into the ternary drug delivery system. Sarda et al explored the interaction between the drug and nanocrystalline apatite (HA) and the drug and iron-doped superparamagnetic apatite (FeHA) and found that FeHA has a stronger adsorption affinity for drugs, while HA can release drugs rapidly; both complexes have good biocompatibility.…”

Section: Calcium-based Materialsmentioning

confidence: 99%

“…Hydroxyapatite (HAp) is the most widely used bone tissue nanocarrier among calcium phosphate nanomaterials, and it has high biocompatibility and good biodegradability because calcium phosphate is an inorganic mineral within human bones and teeth. For drug delivery, it fulfills many important requirements for efficient delivery systems, namely, the ability to incorporate drugs or biomolecules on physically or covalently bound internal and external surfaces and the ability to retain such biomolecules until the particles reach the target site and dissolve, as well as its inherent biodegradability (calcium and phosphate ions) 112,113 . Liu et al .…”

Section: Inorganic Nanomaterialsmentioning

confidence: 99%

Research Progress of Nanomaterials in Chemotherapy of Osteosarcoma

Cai

Chang

et al. 2023

Orthopaedic Surgery

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Osteosarcoma (OS) is a common malignant bone tumor that occurs mostly in children and adolescents. At present, surgery after chemotherapy or postoperative adjuvant chemotherapy is the main treatment plan. However, the efficacy of chemotherapeutic drugs is limited by the occurrence of chemotherapeutic resistance, toxicity to normal cells, poor pharmacokinetic performance, and drug delivery failure. The delivery of chemotherapy drugs to the bone to treat OS may fail for a variety of reasons, such as a lack of selectivity for OS cells, initial sudden release, short‐term release, and the presence of biological barriers (such as the blood‐bone marrow barrier). Nanomaterials are new materials with at least one dimension on the nanometer scale (1–100 nm) in three‐dimensional space. These materials have the ability to penetrate biological barriers and can accumulate preferentially in tumor cells. Studies have shown that the effective combination of nanomaterials and traditional chemotherapy can significantly improve the therapeutic effect. Therefore, this article reviews the latest research progress on the use of nanomaterials in OS chemotherapy.

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“…Inorganic nanocarriers include carbon nanomaterials, [ 32 ] silica NPs, calcium nanomaterials, [ 33 ] gold NPs, [ 34 ] magnetic NPs, [ 35 ] nano‐clay, [ 36 ] and quantum dots. [ 37 ] Inorganic nanocarriers are easy to handle and can be effectively used for biosensing, cell labeling, targeting, imaging, and diagnostics.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review

Liao

Yang

2023

Advanced Science

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Advanced functional two‐dimensional (2D) nanomaterials offer unique advantages in drug delivery systems for disease treatment. Kaolinite (Kaol), a nanoclay mineral, is a natural 2D nanomaterial because of its layered silicate structure with nanoscale layer spacing. Recently, Kaol nanoclay is used as a carrier for controlled drug release and improved drug dissolution owing to its advantageous properties such as surface charge, strong biocompatibility, and naturally layered structure, making it an essential development direction for nanoclay‐based drug carriers. This review outlines the main physicochemical characteristics of Kaol and the modification methods used for its application in biomedicine. The safety and biocompatibility of Kaol are addressed, and details of the application of Kaol as a drug delivery nanomaterial in antibacterial, anti‐inflammatory, and anticancer treatment are discussed. Furthermore, the challenges and prospects of Kaol‐based drug delivery nanomaterials in biomedicine are discussed. This review recommends directions for the further development of Kaol nanocarriers by improving their physicochemical properties and expanding the bioapplication range of Kaol.

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Preparation and application of calcium phosphate nanocarriers in drug delivery

Cited by 18 publications

References 180 publications

Nanomedicines Promote Cartilage Regeneration in Osteoarthritis by Synergistically Enhancing Chondrogenesis of Mesenchymal Stem Cells and Regulating Inflammatory Environment

Nanomedicines Promote Cartilage Regeneration in Osteoarthritis by Synergistically Enhancing Chondrogenesis of Mesenchymal Stem Cells and Regulating Inflammatory Environment

Research Progress of Nanomaterials in Chemotherapy of Osteosarcoma

Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review

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