ZnO nanorods as an intracellular sensor for pH measurements

Willander, Magnus; Al-Hilli, Safaa

doi:10.1063/1.2798582

Cited by 123 publications

(97 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…53(a), the electrochemical potential between the two electrodes was almost linearly proportional to the buffer electrolyte pH within the pH range 4-11, with a sensitivity of about 52 mV/pH. The authors noted that the ZnO nanowires were thermodynamically stable over the tested pH range at room temperature [440]. For the measurement of intracellular pH value, both electrodes were then pushed to penetrate the membrane of a human fat cell.…”

Section: Sensorsmentioning

confidence: 99%

“…reported an intracellular pH sensor [440]. The benefits of using ZnO nanowire arrays are that they have high surface to volume ratio and offer high sensitivity and real-time detection.…”

Section: Sensorsmentioning

confidence: 99%

“…53(b), the two electrodes were in direct contact with the cell cytoplasm, and the intracellular pH value was read to be 6.81. ZnO is [440]. Reproduced with permission nontoxic and biocompatible [441,442].…”

Section: Sensorsmentioning

confidence: 99%

See 2 more Smart Citations

One-dimensional ZnO nanostructures: Solution growth and functional properties

2011

View full text Add to dashboard Cite

One-dimensional (1D) ZnO nanostructures have been studied intensively and extensively over the last decade not only for their remarkable chemical and physical properties, but also for their current and future diverse technological applications. This article gives a comprehensive overview of the progress that has been made within the context of 1D ZnO nanostructures synthesized via wet chemical methods. We will cover the synthetic methodologies and corresponding growth mechanisms, different structures, doping and alloying, positioncontrolled growth on substrates, and finally, their functional properties as catalysts, hydrophobic surfaces, sensors, and in nanoelectronic, optical, optoelectronic, and energy harvesting devices.

show abstract

Section: Sensorsmentioning

confidence: 99%

“…reported an intracellular pH sensor [440]. The benefits of using ZnO nanowire arrays are that they have high surface to volume ratio and offer high sensitivity and real-time detection.…”

Section: Sensorsmentioning

confidence: 99%

See 1 more Smart Citation

One-dimensional ZnO nanostructures: Solution growth and functional properties

2011

View full text Add to dashboard Cite

show abstract

“…Our main effort has been directed towards the construction of tips that are selective for glucose and capable of penetrating the cell membrane, as well as the optimisation of electrochemical potential properties. Tips of borosilicate glass capillaries (0.7 µm in diameter) with grown ZnO nanorods have proven to be a convenient and practical choice, as we have demonstrated with our previously developed intracellular Ca 2+ and pH nanosensors (Asif et al, 2009;Al-Hilli et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose

Asif

Ali

Nur

et al. 2010

Biosensors and Bioelectronics

Self Cite

128

View full text Add to dashboard Cite

In this article, we report a functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose. To adjust the sensor for intracellular glucose measurements, we grew hexagonal ZnO nanorods on the tip of a silver-covered borosilicate glass capillary (0.7 µm diameter) and coated them with the enzyme glucose oxidase. The enzyme-coated ZnO nanorods exhibited a glucose-dependent electrochemical potential difference versus an Ag/AgCl reference micro-electrode. The potential difference was linear over the concentration range of interest (0.5 µM -1000 µM). The measured glucose concentration in human adipocytes or frog oocytes using our ZnO nanorod sensor was consistent with values of glucose concentration reported in the literature; furthermore, the sensor was able to show that insulin increased the intracellular glucose concentration. This nanoelectrode device demonstrates a simple technique to measure intracellular glucose concentration.

show abstract

“…1-3 ZnO nanorods/nanowires are important semiconducting and piezoelectric material structures that have various applications in the field of optoelectronics, 4 biosensors, 5 resonators, 6 electric nanogenerators, 7 and nanolasers. 8 ZnO-based quasi-onedimensional materials have received increasing attention due to their unique characteristics in future nanodevices as nanoscale interconnects and active components of optical electronic devices and nanoelectromechanical systems ͑NEMSs͒.…”

Section: Introductionmentioning

confidence: 99%

Bending flexibility, kinking, and buckling characterization of ZnO nanorods/nanowires grown on different substrates by high and low temperature methods

Riaz

Fulati

Yang

et al. 2008

Journal of Applied Physics

Self Cite

View full text Add to dashboard Cite

Nanomechanical tests of bending flexibility, kinking, and buckling failure characterization of vertically aligned single crystal ZnO nanorods/nanowires were performed quantitatively by nanoindentation technique. These nanostructures were grown by the vapor liquid solid ͑VLS͒ method, a relatively high temperature approach, and the aqueous chemical growth ͑ACG͒ method, a relatively low temperature approach on different substrates, including SiC and Si. The first critical load at the inflection point found for the ZnO nanorods/nanowires grown by ACG method was 105 N on the SiC substrates and 114 N on the Si substrates. The corresponding buckling energies calculated from the force-displacement curves were 3.15ϫ 10 −12 and 2.337ϫ 10 −12 J, respectively. Similarly, for the samples grown by the VLS method, the first critical load at the inflection point and the corresponding buckling energies were calculated from the force-displacement curves as 198 N and 7.03ϫ 10 −12 J on the SiC substrates, and 19 N and 1.805ϫ 10 −13 J on the Si substrates. Moreover, the critical buckling stress, strain, and strain energy were also calculated for all samples. The strain energy for all samples was much less than the corresponding buckling energy. This shows that our as-grown samples are elastic and flexible. The elasticity measurement was performed for all the samples before reaching the first critical and kinking inflection point, and we subsequently observed the bending flexibility, kinking, and buckling phenomena on the same nanorods/nanowires. We observed that the loading and unloading behaviors during the bending test of the as-grown samples were highly symmetrical, and also that the highest point on the bending curves and the first inflection and critical point were very close. ZnO nanorods/nanowires grown on SiC by the ACG method, and those grown by the VLS method on Si substrates, show a linear relation and high modulus of elasticity for the force and displacement up to the first inflection and critical point. The results also show that the elasticity of the ZnO single crystal is approximately linear up to the first inflection point, is independent of the growth method and is strongly dependent on the verticality on the surface of the substrates. In addition, the results show that after the first buckling point, the nanorods/nanowires have plasticity, and become more flexible to produce multiple kinks.

show abstract

ZnO nanorods as an intracellular sensor for pH measurements

Cited by 123 publications

References 28 publications

One-dimensional ZnO nanostructures: Solution growth and functional properties

One-dimensional ZnO nanostructures: Solution growth and functional properties

Functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose

Bending flexibility, kinking, and buckling characterization of ZnO nanorods/nanowires grown on different substrates by high and low temperature methods

Contact Info

Product

Resources

About