ZnO nanoparticles enhanced antibacterial activity of ciprofloxacin against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>

Banoee, Maryam; Seif, Sepideh; Nazari, Zeinab; Jafari-Fesharaki, Parisa; Shahverdi, Hamid Reza; Moballegh, Ali; Mollazadeh-Moghaddam, Kamyar; Shahverdi, Ahmad Reza

doi:10.1002/jbm.b.31615

Cited by 227 publications

(136 citation statements)

References 45 publications

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“…Furthermore, nanoparticles tagged with antibiotics have been shown to increase the concentration of the antibiotics at the site of bacterium-antibiotic interaction, and facilitate in the binding of antibiotics to microorganisms (Allahverdiyev et al 2011). Our results are in terms with the study conducted by Banoee et al (2010) showing better activity of ciprofloxacin nanoparticle combination as compared to ampicillin nanoparticle combination. They reported 27 and 22% increase in inhibition zone areas was observed against S. aureus and E. coli, respectively when ZnO nanoparticles combine with ciprofloxacin.…”

Section: Discussionsupporting

confidence: 83%

“…This is done by the presence of fluore group and carboxyl group on the ciprofloxacin. The fluore group interacts with the chelating Zn atom stabilizing the ciprofloxacinnanoparticle combination whereas carboxyl group serves as an obvious target for chelation by metal ions (Banoee et al 2010). Moreover, presence of doping ion on ZnO nanoparticle surface accelerates generation of reactive oxygen species (rOS) due to coupling or synergistic effects of Mn, Co, Cu and Fe loading.…”

Section: Discussionmentioning

confidence: 99%

“…Further with an increase in concentration of doping synergistic activity increased as interaction between oxygen and dehydrogenase enzyme increases which increases the activity (Sikong et al 2010). Minimal enhanced or unchanged antimicrobial activity of the other tested antibiotics against bacteria and funguscan be elucidated either by formation of weak hydrogen bonds with hydroxylated doped and undoped ZnO nanoparticles or by lack of sufficient targets for interaction (Banoee et al 2010). …”

Section: Discussionmentioning

confidence: 99%

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Synergistic activity of doped zinc oxide nanoparticles with antibiotics: ciprofloxacin, ampicillin, fluconazole and amphotericin B against pathogenic microorganisms

Sharma

Jandaik

Kumar³

2016

An. Acad. Bras. Ciênc.

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Combination therapy of antibiotics and nanoparticles can be used against multi drug resistant microorganisms. Nanoparticles (NPs) have been reported to show antimicrobial activity. The antimicrobial activities of doped ZnO nanoparticles (ZnO NPs) were studied against fungi, gram-positive and gramnegative bacteria using the standard microdilution method. The interaction between the nanoparticle and the antibiotic was estimated by calculating the fractional inhibitory concentration (FIC index) of the combination through checkerboard assay. Experimental results demonstrated that 10% doped zinc oxide nanoparticles (ZnO NPs) exhibited the maximum antimicrobial effect in contrast with that of the 1% loading and pure ZnO nanoparticles. The enhancement in antimicrobial effect was seen when combined with antibiotic. Synergistic and additive effects were found. No antagonistic effect was found. More synergistic effect was observed when combined with ciprofloxacin than ampicillin. Fungus showed only additive effect. The results are quite in terms with MIC clearly depicting that high doping agent is most suitable for combined therapy. 100% synergistic interaction was observed in higher doping with both ciprofloxacin and ampicillin. This study provides a preliminary report of the synergistic activity of nanoparticles with antibiotics against different pathogenic strains. This provides groundwork for further studies on the combination therapy of nanoparticles with antibiotics.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Synergistic activity of doped zinc oxide nanoparticles with antibiotics: ciprofloxacin, ampicillin, fluconazole and amphotericin B against pathogenic microorganisms

Sharma

Jandaik

Kumar³

2016

An. Acad. Bras. Ciênc.

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“…To date, many organic and inorganic compounds have been reported to enhance the antibacterial activity of different antibiotics against many bacteria and fungi resistant test strains [14]. Metallic ions and metallic nanoparticles including zinc and silver have particularly shown promise when used in combination with a number of antibiotics such as ciprofloxacin [15], penicillin G, amoxicillin, erythromycin, clindamycin, vancomycin [16], ampicillin, kanamycin, erythromycin and chloramphenicol [17] in different Gram positive or Gram negative test strains. In a recent approach, Rai et al reported the antibiotic mediated synthesis of Au NPs with potent antimicrobial activity for application in antimicrobial coatings [18].…”

Section: Introductionmentioning

confidence: 99%

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

et al. 2012

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Despite much success in drug design and development, Pseudomonas aeruginosa is still considered as one of the most problematic bacteria due to its ability to develop mutational resistance against a variety of antibiotics. In search for new strategies to enhance antibacterial activity of antibiotics, in this work, the combination effect of gold materials including trivalent gold ions (Au 3+ ) and gold nanoparticles (Au NPs) with 14 different antibiotics was investigated against the clinical isolates of P. aeruginosa, Staphylococcus aureus and Escherichia coli. Disk diffusion assay was carried out, and test strains were treated with the sub-inhibitory contents of gold nanomaterial. Results showed that Au NPs did not increase the antibacterial effect of antibiotics at tested concentration (40 μg/disc). However, the susceptibility of resistant P. aeruginosa increased in the presence of Au 3+ and methicillin, erythromycin, vancomycin, penicillin G, clindamycin and nalidixic acid, up to 147 %. As an individual experiment, the same group of antibiotics was tested for their activity against clinical isolates of S. aureus, E. coli and a different resistant strain of P. aeruginosa in the presence of sub-inhibitory contents of Au 3+, where Au 3+ increased the susceptibility of test strains to methicillin, erythromycin, vancomycin, penicillin G, clindamycin and nalidixic acid. Our finding suggested that using the combination of sub-inhibitory concentrations of Au 3+ and methicillin, erythromycin, nalidixic acid or vancomycin may be a promising new strategy for the treatment of highly resistant P. aeruginosa infections.

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“…Sections were deparaffinized in xylene and subsequently stained with Haematoxylin and Eosin (H and E) for light microscopy. 30 …”

Section: Histopathological Assessmentmentioning

confidence: 99%

Formulation and Evaluation of Therapeutic Potential of Nanoemulsion of a Blend of Antimicrobial Oils

Osonwa¹,

Okechukwu²,

Ihekwereme³

et al. 2018

TJNPR

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ZnO nanoparticles enhanced antibacterial activity of ciprofloxacin against Staphylococcus aureus and Escherichia coli

Cited by 227 publications

References 45 publications

Synergistic activity of doped zinc oxide nanoparticles with antibiotics: ciprofloxacin, ampicillin, fluconazole and amphotericin B against pathogenic microorganisms

Synergistic activity of doped zinc oxide nanoparticles with antibiotics: ciprofloxacin, ampicillin, fluconazole and amphotericin B against pathogenic microorganisms

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

Formulation and Evaluation of Therapeutic Potential of Nanoemulsion of a Blend of Antimicrobial Oils

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