Formulation and Evaluation of Therapeutic Potential of Nanoemulsion of a Blend of Antimicrobial Oils

Osonwa, Uduma Eke; Okechukwu, Simeon; Ihekwereme, Chibueze Peter; Chukwu, Kingsley C.; Eluu, S.C.; Azevedo, Ricardo Bentes

doi:10.26538/tjnpr/v2i2.3

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…16 The possible solution to curb antimicrobial resistance or enhance antimicrobial activity against resistant strains of organism may lie in the use of plants and their products. 17 The renewed interest in the use of medicinal plants in the management of fungal diseases coupled with the increased prevalence of oral candidiasis, has necessitated a need for the development of effective strategies for treatment. In recent times, the plant natural sources are required in the discovery of new antifungals, especially those that may inhibit fungi-specific pathways or act on novel cellular targets.…”

mentioning

confidence: 99%

Evaluation of Zingiber officinale Rosc. and Ocimum basilicum L. Essential Oils-Loaded Gel Base for the Treatment of Oral Candidiasis

2020

TJNPR

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Oral candidiasis is an opportunistic infection of the oral cavity and as the name implies, it is caused by Candida species. The rate of incidence occurs in approximately 5-7% of infants, prevalence in HIV is between 9-31% and approximately 20% in patients with cancer. 1 Predisposing factors such as salivary gland dysfunction, use of dental prostheses, smoking, indiscriminate use of antibiotics, endocrine disorders, nutritional deficiencies, poor oral hygiene, age and immune disorders such as HIV can cause oral candidiasis. 2 The immune system of the host typically controls the proliferation of Candida albicans; but, C. albicans cause severe opportunistic infections in patients with diabetes mellitus, immuno-compromised patients on chemotherapy, immunosuppressive therapeutic agents and patients living with HIV. 3 The drug of choice in candidiasis for non-immunosuppressed adults is either nystatin suspension or clotrimazole douche. However, the numerable side effects and the growing incidence of drug-resistant fungal diseases pose a unique task to antifungal drug discovery. 4

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confidence: 99%

Evaluation of Zingiber officinale Rosc. and Ocimum basilicum L. Essential Oils-Loaded Gel Base for the Treatment of Oral Candidiasis

2020

TJNPR

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The antimicrobial potential of essential oils and their nanoparticulate formulations as effective antifungals

Orchard,

Ebrahim,

Khan

et al. 2024

Journal of Essential Oil Bearing Plants

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Encapsulation of Essential Oils within Lipid-Based Formulations for Enhanced Antimicrobial Activity

et al. 2023

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Aromatic plants have been used since ancient times for their medicinal properties, including potent antimicrobial activity. Strong evidence indicates that plant extracts, in general, and essential oils (EOs), in particular, can act as effective antimicrobial agents against a wide spectrum of pathogenic microorganisms. However, their poor water solubility and stability, as well as their high volatility, make the administration of EOs to achieve the desired therapeutic effects particularly challenging. Therefore, these features severely limit the application of EOs in the pharmaceutical field. In this context, nanotechnology-based strategies for developing nano-scaled carriers for the efficient delivery of EOs might offer potential solutions. In particular, considering the lipophilic nature of EOs, lipid-based nanocarriers represent the most suitable vehicles for the effective encapsulation and delivery of EOs. This chapter provides an overview of the different chemical compositions due to various endogenous and/or exogenous factors of a selection of oils and the most recent lipid-based encapsulation strategies to enhance their antimicrobial activity and promote their pharmaceutical application.

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Formulation and Evaluation of Therapeutic Potential of Nanoemulsion of a Blend of Antimicrobial Oils

Cited by 3 publications

References 27 publications

Evaluation of Zingiber officinale Rosc. and Ocimum basilicum L. Essential Oils-Loaded Gel Base for the Treatment of Oral Candidiasis

Evaluation of Zingiber officinale Rosc. and Ocimum basilicum L. Essential Oils-Loaded Gel Base for the Treatment of Oral Candidiasis

The antimicrobial potential of essential oils and their nanoparticulate formulations as effective antifungals

Encapsulation of Essential Oils within Lipid-Based Formulations for Enhanced Antimicrobial Activity

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