ZnO nanoparticles as drug delivery agent for photodynamic therapy

Abstract

Multidrug resistance (MDR) limits the success of many tumoricidal drugs. Non-significant accumulation of the drug into the target site is one major problem in photodynamic therapy. Nanoparticles are extensively used as efficient drug carriers in various local infectious and premalignant biological tissues. Due to their unique physical and chemical properties, PEGylated zinc oxide nanoparticles (ZnO NPs) exhibit high drug loading capacities, sustained drug release profiles and long-term anticancer efficacy. (Polyethylene glycol) PEG-zinc oxide nanoparticles were synthesized using the aquis chemical technique. Morphology/structural analysis of the said nanoparticles was confirmed by applying many techniques, e.g. scanning electron microscopy (SEM) and XRD. Average grain size of the nanoparticles, which was ≈100 nm, was calculated by applying the Scherrer formula. The PEGylated ZnO NPs were loaded with protoporphyrin IX (PpIX) to enhance the capability of drug carrying potency. Current work focused on the comparison of the cell killing effect (apoptosis/necrosis) by functionalizing different nanostructures via PEGylated ZnO NPs and bare ZnO NPs using the free-standing drug delivery procedure. ZnO NPs were used as anticancer drug vehicles because of their biocompatibility and bio-safety profile. The apoptotic effect of PEGylated tumoricidal drugs has been studied in human muscle carcinoma (RD cell line) in the dark as well as under laser exposure. It was concluded that PpIX localization was a significant time greater using encapsulation as compared to a conventional drug delivery system. This new technique may find excellent opportunities in the field of nanomedicine, especially in a multidrug delivery system.

Structure, morphology and luminescence properties of sol-gel method synthesized pure and Ag-doped ZnO nanoparticles

“…A greyish-white patch was formed on the top of the sample thereby indicating that the metal ions were diffused on the surface of the ZnO nanoparticles. From the SEM, as emphasized by Alam et al the server aggregated particle size was found and the results were closer to X-rd analysis [15]. The significant SEM particles dimension is higher than the corresponding crystallite size i.e.…”

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

“…Many promising techniques still figured out several issues like limitations of reliable protocols such as appropriate labelling, interaction of hydrophobic and hydrophilic nanoparticles, and proper visibility of cells from data for disease recognition, to achieve a minimal damaging effect in a healthy site [61][62][63][64].…”

Paramagnetism of cobalt-doped ZnO nanoparticles obtained by microwave solvothermal synthesis

“…Thus, ZnO has been reckoned as an excellent UV shielding material, characterized by photo-fastness and absorptivity over a broad UV range, in contrast to other organic and inorganic UV shielding materials [ 9 ]. Moreover, ZnO is applied to cosmetics [ 10 ], optoelectronic devices [ 11 – 14 ], solar cells [ 10 ], catalysts [ 15 ], energy storage (battery) materials [ 16 ], fast data storage [ 17 ], light-emitting diodes (LEDs) [ 18 ], gas sensors [ 10 ], thermoelectric devices [ 19 ], varistors [ 20 – 21 ], window materials for displays [ 21 ], laser technology [ 10 ], surface acoustic wave devices [ 22 ] and drug delivery [ 23 ].…”