ZnO and TiO2 Nanoparticles Genotoxicity According to their Structural and Morphological Characteristics Used for Medical Purposes

Głód, M; Damir, Daniela; Nichitus, Simona; Calin, Gabriela; Duceac, Letiția Doina; Gorgan, Dragoș Lucian; Tascu, Sorin; Ciuhodaru, Mădălina Irina

doi:10.37358/rc.18.3.6159

Cited by 3 publications

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“…On the other hand, it is important to mention the efficacy of ZnO and TiO 2 nanoparticles as coatings for medical devices. M. Glod et al [15] studied the genotoxicity of these particles on neoplastic HeLa and normal Vero cells and they found minor effects of the tested compounds on the cells viability, that suggesting a reduced cytotoxicity on both cell lines, but a better tolerability was observed in the case of the normal cells.…”

Section: Resultsmentioning

confidence: 99%

Comparative Characterization of Different Samples Containing Nano-ZnO Particles with Applicability in Topical Therapies

Chioibaş¹,

Borcan²,

Mederle³

et al. 2019

Mat.Plast.

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Zinc oxide (ZnO) is an inorganic compound used for its antiseptic and skin healing properties. It is an excellent protective filter against UV radiation and it can be used as white pigment in pharmaceutical preparations. In this study, nano-ZnO particles were obtained by ultrasound treatment, and respectively by repeated freezing/heating process. The influence of synthesis method and of ultrasound generator parameters on the particles size and stability was observed. The results reveal that were obtained samples with a very good stability and sizes between 15 and 96 nm. It was found that synthesis based on ultrasound treatment lead to the formation of nanoparticles with lower sizes.

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Section: Resultsmentioning

confidence: 99%

Comparative Characterization of Different Samples Containing Nano-ZnO Particles with Applicability in Topical Therapies

Chioibaş¹,

Borcan²,

Mederle³

et al. 2019

Mat.Plast.

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“…Antibioresistance is considered a global public health threat being implicated in elevated mortality and morbidity rates as a consequence of hospitalization [1][2][3]. Studies revealed that between 3% and 5% of hospitalized patients leave the care unit acquiring healthcare-associated infections [4][5][6][7][8][9][10][11][12][13]. The most widely used antibiotics to treat some bacterial infections by inhibiting cell wall biosynthesis are â-lactam antibiotics.…”

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confidence: 99%

Study on the Mechanism of Antibiotic Resistance

Duceac¹,

Ţarcă²,

Ciuhodaru³

et al. 2019

Rev. Chim.

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A major public health threat that affects humans is recognized worldwide as an occurrence of antibiotic resistance regarding bacterial pathogen. Multidrug resistant microorganisms appeared in the hospitals and in the community settings respectively insinuating that the antibiotic-resistant bacteria are present even outside the hospital environment. First stage of bacterial adaptation and the top of evolution is represented by the bacterial response to the drug assault. Then, the survival of the fittest is a consequence of the biochemical and genetically alteration. Therefore, of extreme importance are the innovative methods and devices for therapeutic approaches against antibiotic-resistant microorganisms.

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“…Numerous studies demonstrating the efficacy and versatility of that matrix-forming agent are provided in the literature [8]. Similar studies were carried out in the literature [9][10][11][12][13][14][15][16][17][18][19][20][21].…”

mentioning

confidence: 99%

Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate

Crețeanu¹,

Ştefanache²,

Vieriu³

et al. 2019

Rev. Chim.

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The study is based on new oral matrix tablets based on Kollidon®SR and chitosan, formulated in order to optimize the low oral bioavailability of amiodarone, a class III antiarrhythmic drug. Pharmacotechnical characterization included the analysis of flowability and compressibility properties (flow time, friction coefficient, angle of repose, Hausner ratio, Carr Index), and of pharmaco-chemical characteristics (mass and dose uniformity, thickness, diameter, mechanical strength, friability, degree of softening, in vitro release profile) of the tablets obtained using direct compression method. The results obtained have shown that both Kollidon®SR and chitosan may be used as matrix forming agents when combined with amiodarone. In vitro dissolution tests revealed that the nine formulations studied provided a prolonged release of amiodarone when compared to an industrial pharmaceutical product formulated as conventional release tablets.

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ZnO and TiO2 Nanoparticles Genotoxicity According to their Structural and Morphological Characteristics Used for Medical Purposes

Cited by 3 publications

References 0 publications

Comparative Characterization of Different Samples Containing Nano-ZnO Particles with Applicability in Topical Therapies

Comparative Characterization of Different Samples Containing Nano-ZnO Particles with Applicability in Topical Therapies

Study on the Mechanism of Antibiotic Resistance

Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate

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