ZnCl2-catalyzed synthesis of α-dithiocarbamato-alkyl-β-naphthols via the Betti reaction under solvent-free conditions

Zn Complex on Tryptophan-Functionalized MCM-41 as an Efficient and Promising Reusable Nanocatalyst in One-Pot Three-Component Synthesis of Amino Benzyl Quinolinols and Naphthols via a Betti Reaction

“…This type of reaction usually occurs in the presence of a catalyst . Among the various reactions, Betti’s basic synthesis (modified Mannich reaction or Mannich amino alkylation) is found to be of great importance because of the mild conditions of reaction for forming C–C and C–N bonds. , These compounds are important due to their applications as chiral ligands − and their essential medicinal properties including anti-inflammatory, anthelmintic, antifungal, antibacterial, analgesic, anticonvulsant, anti-microbial, antimalarial, anticancer, and antiviral properties. − Three-component Betti reaction have been catalyzed with various zinc catalysts such as diisopropenyl zinc, arylzinc, , ZnCl 2 , Zn­(OAc) 2 ·2H 2 O, diethylzinc, etc.…”

Multicomponent synthesis of fully substituted thiazoles using glycine-based dithiocarbamates, acetic anhydride and nitroalkenes

“…17,18 They play dual roles of electrophile and nucleophile in organic synthesis and have been applied successfully for the preparation of thioureas, 18 isothiocyanates, 19 cyanamides, 20 protected aldehydes, 21 and amides. 22 They have also found application as amine surrogates in the Betti reaction 23 and are useful in the protection of amino groups in peptide synthesis. 24 In addition, they are versatile intermediates for the preparation of N,S-and S,S-heterocycles.…”

An efficient, multicomponent synthesis of aminoalkylnaphthols via Betti reaction using ZSM‐5 as a recoverable and reusable catalyst

“…Therefore, the synthesis of this core has received increasing attention to synthetic organic chemists and biologists. Recently, several methodologies and green procedures for the synthesis of Betti reactions have also been successfully developed using catalysts such as Brønsted and Lewis acids such as SnCl 4 .5H 2 O, [ 32 ] ionic liquids, [ 33 ] nano‐sulfated zirconia, [ 34 ] ZrO (OTf) 2 , [ 35 ] polymer‐supported sulfonic acid, [ 36 ] Bi (NO 3 ) 3 .5H 2 O, [ 37 ] [HMIM]C (CN) 3 , [ 38 ] nanocrystalline MgO, [ 39 ] supported copper triflate, [ 40 ] ZnCl 2 , [ 41 ] GO‐MnO 2 ‐Au ternary nanocomposite, [ 42 ] and sulfated polyborate. [ 43 ] Although these methods/reactions have their advantages, there are demerits such as the use of expensive low selectivity catalysts, harsh reaction conditions, expensive reagents, moisture sensitivity, toxic solvent/reagents, the use of excess or stoichiometric amounts of reagents, non‐recoverability of the catalysts, and/or recoverable with tedious separation procedures, involving lots of toxic waste generation besides a long reaction time and low yield of the desired product.…”