Multicomponent synthesis of fully substituted thiazoles using glycine-based dithiocarbamates, acetic anhydride and nitroalkenes

Abstract

Reaction of glycine-based dithiocarbamates with nitroalkenes in the presence of acetic anhydride was utilized for the synthesis of fully substituted 2-(alkylsulfanyl)-4-(nitroalkyl)-5-acyloxy-1,3-thiazoles. The reaction proceeds via the in situ formation of...

Catalyst free one pot three components synthesis of 2-iminothiazoles from nitroepoxides and thiourea

“…In continuation of our interest on the synthesis of N,S-heterocycles and the chemistry of nitroepoxides [49][50][51][52] , herein we report a novel catalyst-free one-pot three-component route for the synthesis of 2-imino-1,3-thiazolines via nitroepoxide ring opening reaction (Scheme 1f). Reaction of ethylamine 1 with phenyl isothiocyanate 2 and nitroepoxide 3a was considered as a model reaction for optimization of the reaction conditions.…”

Catalyst-Free One-Pot Three-Component Synthesis of 2-Iminothiazoles from Nitroepoxides

“…In continuation of our interest on the synthesis of N,S-heterocycles and the chemistry of nitroepoxides, [45][46][47][48] herein we report a novel catalyst-free one-pot three-component route for the synthesis of 2-imino-1,3thiazolines via nitroepoxide ring opening reaction (Scheme 1f). Reaction of ethylamine 1 with phenyl isothiocyanate 2 and nitroepoxide 3a was considered as a model reaction for optimization of the reaction conditions.…”