Zn-Releasing FHA Coating and Its Enhanced Osseointegration Ability

Abstract

In this study, we present a novel coating with Zn-releasing ability that promotes osseointegration of Ti6Al4V implants. The coatings were prepared by a sol-gel technique, and nanosized Zn-containing b-tricalcium phosphate particles were added to the Ca(NO 3 ) 2 -P 2 O 5 -HPF 6 sol system to incorporate Zn ions into fluoridated hydroxyapatite (FHA) coatings. The derived Zn-releasing fluoridated hydroxyapatite (ZTFHA) coatings demonstrated a slow and sustained Zn release behavior. The ZTFHA coatings were able to support cell growth of osteoblastlike cell cultures and promoted an obvious increase in cell viability compared with FHA coating alone. The histological analysis of the ZTFHA coating showed direct bonding to bony tissue and significantly higher bone contact than with FHA coating alone. The ZTFHA coating with its slow and sustained Zn release shows promise as a medium for significantly enhancing osseointegration and allowing cementless stable fixation of orthopedic implants.

Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits

“…Our results showed that Zn-modified coatings significantly enhance proliferation in BM-PCs and are non-cytotoxic compared with CaSiO 3 coatings and uncoated Ti-6Al-4V at all tested time points. Moreover, the cell proliferation rate correlated with the increase in the Zn/Ca mol ratio, consistent with our previous study and other studies reporting the stimulatory effect of zinc on osteoblastic cell behavior 41, 47, 50 . Therefore, the enhanced cell viability on the Zn-Ca 0.3 coating may be attributed to proper Zn release.…”

Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces

“…A Zn-containing α-tricalcium phosphate (αZnTCP) was shown to promote new bone formation (Li et al, 2009). Fluoridated hydroxyapatite (FHA) coatings with incorporated Zn ions improve cell viability and new bone formation (Miao et al, 2011). However, although Zn-Ca phosphate coatings have a positive effect on bone formation, a study by Kawamura et al (2003) showed that they may increase bone resorption at later stages.…”

Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant

“…In [45]. Zn-releasing FHA coatings were able to support the growth of osteoblast-like cell cultures and promote an evident increase in cell viability compared with FHA coatings [46]. Uysal et al study [17] suggested that Zn 2+ incorporation into the structure results in an increase in cell proliferation and ALP activity of cells.…”