Zn(OAc)2·2H2O: a versatile catalyst for the one-pot synthesis of propargylamines

Green synthesis of CuO nanoparticles by aqueous extract of Anthemis nobilis flowers and their catalytic activity for the A3 coupling reaction

“…In the last decade many efforts have been done to develop new methodologies for the synthesis of propargylamines through one-pot three-component condensation reaction (A 3 ) of aldehydes, amines, and alkynes in the presence of homogeneous catalysts such as Zn salts, Cu salts, Fe salts, Ag salts, Au salts [4][5][6][7][8][9].…”

Search of antimycobacterial activities in hybrid molecules with benzopyran skeleton

“…Further, in order to see the antitubercular activity profiles in the hybrid compounds of three moieties the acetylenes, chroman, and cyclic amines, a three component reactions of the above chromanyl carbaldehyde 5 with different acetylenes and cyclic amines in the presence of zinc(II) acetate (Ramu et al, 2007) were carried out separately to get the desired 4-(1-(2,2-dimethylchroman-6-yl)-3-phenylprop-2-ynyl) cyclic amines (14-18) in good yields (Scheme 5).…”

Copper-Catalyzed Coupling of Alkynes and Amines for the Synthesis of Propargyl Amines in the Presence of PhI(OAc)2

“…通常, 合成炔丙胺有以下几种方法: 利用叔胺与炔 基锂试剂或格氏试剂分步反应制备 [5] , 或者苯并三唑与 炔基铝试剂的取代反应制备 [6] , 这两种方法因需要使用 存在较大危险性的化学当量的金属试剂, 因此限制了其 应用; 近十年来发展起来的 A3 反应, 即端炔、醛、胺等 三组分在金属 Cu [7] 、Ag [8] 、Au [9] 、Fe [10] 、Zn [11] 、In [12] 、 Co [13] 等催化剂条件下, 通过偶联反应合成炔丙胺; 此 外, 近年来还发展了一类利用端炔、二卤甲烷、胺等三 组分偶联合成炔丙胺化合物的反应, 即 AHA 偶联反应, 对于该反应的研究也很多, 但主要局限于对不同催化剂 的考察上, 如 Cu [14] 、Ag [15] 、Co [16] 、In [17] 、Au [18] 等. 虽 图 1 炔丙胺类化合物的两种主要合成方法 Scheme 1 Two main methods for the synthesis of propargylic amines 1 结果与讨论 …”