Zn-doped hydroxyapatite in biomedical applications

Uysal, İdil; Yılmaz, Bengi; Evis, Zafer

doi:10.1007/s41779-021-00583-4

Cited by 40 publications

(14 citation statements)

References 139 publications

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“…Recently, zinc has attracted much interest because it can be used as a doping element in the HAp structure [20][21][22] and can improve cell proliferation, viability, and adhesion [23], as well as offering antibacterial effects, which are useful in preventing implant-related infections [24]. Moreover, zinc is one of the essential elements of the human body, with an important role in the regulation of bone formation [25]. Thus, through this strategy, by combining HAp with Zn, coatings with enhanced surface characteristics can be designed.…”

Section: Of 16mentioning

confidence: 99%

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

et al. 2022

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The current research aim is to biofunctionalize pure titanium (Ti, grade IV) substrate with titania nanotubes and Zn doped hydroxyapatite-based coatings by applying a duplex electrochemical treatment, and to evaluate the influence of Zn content on the physico-chemical properties of hydroxyapatite (HAp). The obtained nanostructured surfaces were covered with HAp-based coatings doped with Zn in different concentrations by electrochemical deposition in pulsed galvanostatic mode. The obtained surfaces were characterized in terms of morphology, elemental and phasic composition, chemical bonds, roughness, and adhesion. The nanostructured surface consisted of titania nanotubes (NT), aligned, vertically oriented, and hollow, with an inner diameter of ~70 nm. X-Ray Diffraction (XRD) analysis showed that the nanostructured surface consists of an anatase phase and some rutile peaks as a secondary phase. The morphology of all coatings consisted of ribbon like-crystals, and by increasing the Zn content the coating became denser due to the decrement of the crystals’ dimensions. The elemental and phase compositions evidenced that HAp was successfully doped with Zn through the pulsed galvanostatic method on the Ti nanostructured surfaces. Fourier Transform Infrared spectroscopy (FTIR) and XRD analysis confirmed the presence of HAp in all coatings, while the adhesion test showed that the addition of a high quantity leads to some delamination. Based on the obtained results, it can be said that the addition of Zn enhances the properties of HAp, and through proper experimental design, the concentration of Zn can be modulated to achieve coatings with tunable features.

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Section: Of 16mentioning

confidence: 99%

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

et al. 2022

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“…In summary, this paper demonstrated that Er:YAG laser irradiation treatment of HAp-based materials can modify the chemical composition, microstructure and defects, as well as mechanical hardness of the materials, showing a dependence not only on laser power, but also on initial composition (i.e., the content of HPO 4 , x ). These observations could help in designing future tooth whitening by laser treatment and the production of HAp coating, because of the important role of chemical nonstoichiometry in HAp materials [ 28 , 47 ]. For laser whitening treatments, since the whitening agents, bleaching gel, and laser irradiation can cause an alteration to the microstructure and mechanical properties of HAp or enamel, the distinct variations of the Vickers hardness in HAp ceramics and molar teeth subjected to laser irradiation for enamel reinforcement suggest a need for careful consideration of both the stoichiometric alteration of the teeth by the whitening treatment and the power of clinic laser irradiation.…”

Section: Discussionmentioning

confidence: 99%

Raman Analyses of Laser Irradiation-Induced Microstructural Variations in Synthetic Hydroxyapatite and Human Teeth

Imamura

Zhu

Adachi

et al. 2022

JFB

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The microstructural and molecular-scale variations induced by laser irradiation treatment on human teeth enamel in comparison with synthetic hydroxyapatite (HAp) were examined through Raman microprobe spectroscopy as a function of irradiation power. The results demonstrated that laser irradiation could modify stoichiometry, microstructure, and the population of crystallographic defects, as well as the hardness of the materials. These modifications showed strong dependences on both laser power and initial nonstoichiometric structure (defective content of HPO4), because of the occurrence of distinct reactions and structural reconstruction. The reported observations can redirect future trends in tooth whitening by laser treatment and the production of HAp coatings because of the important role of stoichiometric defects.

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“…It is predicted that the application of Zn 2+ and Fe 3+ promotes wound remodeling. [ 29 ] After evaluation in vivo, the authors found that 98% of the preformed biofilm was eliminated upon treatment with a NIR laser and that simultaneous Fe 2 O 3 ‐FeOOH/TiO 2 coating accelerated the repair of damaged tissue. Ions not only have antibacterial capability but also can regulate cell behavior such as enhancing cell activity and cell phenotypic differentiation.…”

Section: Exogenous Stimuli‐responsive Platformsmentioning

confidence: 99%

Environment‐Responsive Therapeutic Platforms for the Treatment of Implant Infection

Dong

et al. 2023

Adv Healthcare Materials

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The application of medical implants has greatly improved the survival rate and life quality of patients. Nevertheless, in recent years, there are increasing cases of implant dysfunction or failure because of bacterial infections. Despite significant improvements in biomedicine, there are still serious challenges in the treatment of implant‐related infections. With the formation of bacterial biofilms and the development of bacterial resistance, these limitations lead to a low efficacy of conventional antibiotics. To address these challenges, it is urgent to exploit innovative treatment strategies for implant‐related infections. Based on these ideas, environment‐responsive therapeutic platforms with high selectivity, low drug resistance, and minor dose‐limiting toxicity have attracted widespread attention. By using exogenous/endogenous stimuli, the antibacterial activity of therapeutics can be activated on demand and exhibit remarkable therapeutic effects. Exogenous stimuli include photo, magnetism, microwave, and ultrasound. Endogenous stimuli mainly include the pathological characteristics of bacterial infections such as acidic pH, anomalous temperature, and abnormal enzymatic activities. In this review, the recent progress of environment‐responsive therapeutic platforms with spatiotemporally controlled drug release/activation is systematically summarized. Afterward, the limitations and opportunities of these emerging platforms are highlighted. Finally, it is hoped that this review will offer novel ideas and techniques to combat implant‐related infections.

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Zn-doped hydroxyapatite in biomedical applications

Cited by 40 publications

References 139 publications

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

Raman Analyses of Laser Irradiation-Induced Microstructural Variations in Synthetic Hydroxyapatite and Human Teeth

Environment‐Responsive Therapeutic Platforms for the Treatment of Implant Infection

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