Zn/Ag micro-galvanic couples formed on titanium and osseointegration effects in the presence of S. aureus

Jin, Guodong; Qin, Hui; Cao, Huiliang; Qiao, Yan; Zhao, Yaochao; Peng, Xiaochun; Zhang, Xianlong; Liu, Xuanyong; Chu, Paul K.

doi:10.1016/j.biomaterials.2015.06.040

Cited by 99 publications

(69 citation statements)

References 38 publications

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“…Furthermore, Zn 2+ acts as an activator or coactivator of a variety of proteins involved in osteogenesis including the earliest determinant of osteoblast differentiation runt‐related transcription factor 2 (Runx2) and its downstream target gene Osterix, a zinc finger motif containing transcription factor 7. Additionally, incorporation of zinc into biomaterials has been observed to enhance bone formation and mineralization 8. These observations indicate that Zn 2+ homeostasis might contribute to citrate accumulation and deposition in bone apatite.…”

Section: Introductionmentioning

confidence: 99%

Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation

Huang

et al. 2018

Advanced Science

101

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Citrate is essential to biomineralization of the bone especially as an integral part of apatite nanocomposite. Citrate precipitate of apatite is hypothesized to be derived from mesenchymal stem/stromal cells (MSCs) upon differentiation into mature osteoblasts. Based on 13C‐labeled signals identified by solid‐state multinuclear magnetic resonance analysis, boosted mitochondrial activity and carbon‐source replenishment of tricarboxylic acid cycle intermediates coordinate to feed forward mitochondrial anabolism and deposition of citrate. Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc‐Runx2/Osterix‐ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Furthermore, age‐related bone loss is associated with Zn2+ and citrate homeostasis; whereas, restoration of Zn2+ uptake alleviates age‐associated declining osteogenic capacity and amount of citrate deposition. Together, these results indicate that citrate is not only a key metabolic intermediate meeting the emerging energy demand of differentiating MSCs but also participates in extracellular matrix mineralization, providing mechanistic insight into Zn2+ homeostasis and bone formation.

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Section: Introductionmentioning

confidence: 99%

Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation

Huang

et al. 2018

Advanced Science

101

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“…Thus, efforts to reduce the biotoxicity of Ag are urgent needed. For bone implant, some researchers found that Ag NP–loaded Zn materials have obvious improved bactericidal ability but low cytotoxicity because of the microgalvanic couple formation that anode Zn can protect cathode Ag from being oxidized 9. Galvanic couples are efficient way to reduce the toxicity of cathodic Ag.…”

Section: Introductionmentioning

confidence: 99%

Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe₃O₄ Heterostructures with Reduced Cytotoxicity

Zhang

Yang

et al. 2018

Advanced Science

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The unique physicochemical properties of silver nanoparticles offer a large potential for biomedical application, however, the serious biotoxicity restricts their usage. Herein, nanogalvanic couple Ag–Fe@Fe3O4 heterostructures (AFHs) are designed to prevent Ag+ release from the cathodic Ag by sacrificial anodic Fe, which can reduce the cytotoxicity of Ag. AFHs are synthesized with modified galvanic displacement strategy in nonaqueous solution. To eliminate the restriction of lattice mismatch between Fe and Ag, amorphous Fe@Fe3O4 nanoparticles (NPs) are selected as seeds, meanwhile, reductive Fe can reduce Ag precursor directly even at as low as 20 °C without additional reductant. The thickness of the Fe3O4 shell can influence the amorphous properties of AFHs, and a series of Janus‐ and satellite‐like AFHs are synthesized. A “cut‐off thickness” effect is proposed based on the abnormal phenomenon that with the increase of reaction temperature, the diameter of Ag in AFHs decreases. Because of the interphase interaction and the coupling effect of Ag and Fe@Fe3O4, the AFHs exhibit unique optical and magnetic properties. This strategy for synthesis of monodisperse heterostructures can be extended for other metals, such as Au and Cu.

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“…Therefore, it is highly desirable to introduce antimicrobial agents into implant surfaces to provide antibacterial activities and prevent peri-implant infections [13][14][15][16][17]. In comparison with organic antibiotics, inorganic antibacterial metal elements (e.g., silver (Ag) [18][19][20][21][22], copper (Cu) [23][24][25][26] and zinc (Zn) [27][28][29]) have attracted great attention due to their perfect stabilities, superior broad-spectrum antibacterial properties, relatively low toxicity to human cells and low risk of producing resistant strains [30,31].…”

Section: Introductionmentioning

confidence: 99%

Review of Antibacterial Activity of Titanium-Based Implants’ Surfaces Fabricated by Micro-Arc Oxidation

Zhang

Wang

et al. 2017

Coatings

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Ti and its alloys are the most commonly-used materials for biomedical applications. However, bacterial infection after implant placement is still one of the significant rising complications. Therefore, the application of the antimicrobial agents into implant surfaces to prevent implant-associated infection has attracted much attention. Scientific papers have shown that inorganic antibacterial metal elements (e.g., Ag, Cu, Zn) can be introduced into implant surfaces with the addition of metal nanoparticles or metallic compounds into an electrolyte via micro-arc oxidation (MAO) technology. In this review, the effects of the composition and concentration of electrolyte and process parameters (e.g., voltage, current density, oxidation time) on the morphological characteristics (e.g., surface morphology, bonding strength), antibacterial ability and biocompatibility of MAO antimicrobial coatings are discussed in detail. Anti-infection and osseointegration can be simultaneously accomplished with the selection of the proper antibacterial elements and operating parameters. Besides, MAO assisted by magnetron sputtering (MS) to endow Ti-based implant materials with superior antibacterial ability and biocompatibility is also discussed. Finally, the development trend of MAO technology in the future is forecasted.

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Zn/Ag micro-galvanic couples formed on titanium and osseointegration effects in the presence of S. aureus

Cited by 99 publications

References 38 publications

Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation

Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation

Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe₃O₄ Heterostructures with Reduced Cytotoxicity

Review of Antibacterial Activity of Titanium-Based Implants’ Surfaces Fabricated by Micro-Arc Oxidation

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Zn/Ag micro-galvanic couples formed on titanium and osseointegration effects in the presence of S. aureus

Cited by 99 publications

References 38 publications

Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation

Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation

Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe3O4 Heterostructures with Reduced Cytotoxicity

Review of Antibacterial Activity of Titanium-Based Implants’ Surfaces Fabricated by Micro-Arc Oxidation

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Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe₃O₄ Heterostructures with Reduced Cytotoxicity