Review of Antibacterial Activity of Titanium-Based Implants’ Surfaces Fabricated by Micro-Arc Oxidation

He, Xiaojing; Zhang, Xiangyu; Wang, Xin; Qin, Lin

doi:10.3390/coatings7030045

Cited by 69 publications

(39 citation statements)

References 111 publications

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“…Such molecules may prevent the adhesion of NPs to the cell barrier, and even regulate the exchange flow of ions through the bacterial cell membrane, thus reducing the killing effect of the NPs [40,73]. However, NPs are able to interact with the bacterial cell membrane, since the NP surface atoms can also bind with the negatively charged carboxyl and phosphate groups present in the bacterial cell membrane [25,40,74].…”

Section: Membrane Damagementioning

confidence: 99%

Antimicrobial Nanostructured Coatings: A Gas Phase Deposition and Magnetron Sputtering Perspective

et al. 2020

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Counteracting the spreading of multi-drug-resistant pathogens, taking place through surface-mediated cross-contamination, is amongst the higher priorities in public health policies. For these reason an appropriate design of antimicrobial nanostructured coatings may allow to exploit different antimicrobial mechanisms pathways, to be specifically activated by tailoring the coatings composition and morphology. Furthermore, their mechanical properties are of the utmost importance in view of the antimicrobial surface durability. Indeed, the coating properties might be tuned differently according to the specific synthesis method. The present review focuses on nanoparticle based bactericidal coatings obtained via magneton-spattering and supersonic cluster beam deposition. The bacteria–NP interaction mechanisms are first reviewed, thus making clear the requirements that a nanoparticle-based film should meet in order to serve as a bactericidal coating. Paradigmatic examples of coatings, obtained by magnetron sputtering and supersonic cluster beam deposition, are discussed. The emphasis is on widening the bactericidal spectrum so as to be effective both against gram-positive and gram-negative bacteria, while ensuring a good adhesion to a variety of substrates and mechanical durability. It is discussed how this goal may be achieved combining different elements into the coating.

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Section: Membrane Damagementioning

confidence: 99%

Antimicrobial Nanostructured Coatings: A Gas Phase Deposition and Magnetron Sputtering Perspective

et al. 2020

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“…Several studies have focused on the incorporation of Zn onto a Ti surface by MAO treatment [58][59][60][61][62][63][64]. Hu et al [59], Zhang et al [61], Zhang et al [62] and Du et al [63] reported that Zn-incorporated TiO 2 coatings showed good antibacterial activity against both Escherichia coli (E. coli) and Staphylococcus aureus.…”

Section: Introductionmentioning

confidence: 99%

Chemical and Biological Roles of Zinc in a Porous Titanium Dioxide Layer Formed by Micro-Arc Oxidation

et al. 2019

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This study investigated the time transient effect of zinc (Zn) in the porous titanium dioxide formed by micro-arc oxidation (MAO) treatment routinely performed for Zn-containing electrolytes. The aim of our analysis was to understand the changes in both the chemical and biological properties of Zn in physiological saline. The morphology of the Zn-incorporated MAO surface did not change, and a small amount of Zn ions were released at early stages of incubation in saline. We observed a decrease in Zn concentration in the oxide layer because its release and chemical state (Zn2+ compound to ZnO) changed over time during incubation in saline. In addition, the antibacterial property of the Zn-incorporated MAO surface developed at late periods after the incubation process over a course of 28 days. Furthermore, osteogenic cells were able to proliferate and were calcified on the specimens with Zn. The changes related to Zn in saline had non-toxic effects on the osteogenic cells. In conclusion, the time transient effect of Zn in a porous titanium dioxide layer was beneficial to realize dual functions, namely the antibacterial property and osteogenic cell compatibility. Our study suggests the importance of the chemical state changes of Zn to control its chemical and biological properties.

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“…To preserve the superior mechanical properties of Ti alloys' bulk and improve the hardness and wear resistance of their surface, surface modification is one of the methods often used. Surface modification techniques may include micro-arc oxidation [7], ion implantation [8], plasma spraying [9], physical vapor deposition [10], the sol-gel technique [11], and plasma-assisted chemical vapor deposition [12]. In recent years, the laser cladding process (as an advanced and promising surface modification technique) has been used to prepare coatings to improve tribological property or medical biocompatibility of titanium alloys [13].…”

Section: Introductionmentioning

confidence: 99%

Laser Cladding of Ti-Based Ceramic Coatings on Ti6Al4V Alloy: Effects of CeO2 Nanoparticles Additive on Wear Performance

et al. 2019

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Ti-based ceramic coatings on Ti6Al4V substrates were successfully prepared through a laser cladding process using pre-placed starting materials of TiCN + SiO2 mixed powder without or with adding a 3 wt % CeO2 nanoparticles additive, aiming at improving the wear resistance of the Ti6Al4V alloy for biological applications. The effects of the CeO2 nanoparticles additive on the microstructure, microhardness, and wear performance of the coatings were analyzed in detail. The observations showed that the main compositions of the cladding coating were TiCN and TiN phase. Compared to the coatings without CeO2, the coatings modified with CeO2 nanoparticles led to more excellent mechanical properties. The average microhardness of the coatings modified with CeO2 nanoparticles was approximately 1230 HV0.2, and the wear volume loss of the coatings modified with CeO2 nanoparticles was approximately 14% less than that of the coatings without CeO2 under a simulated body fluid (SBF) lubrication environment. The major reasons included that the microstructure of the coatings modified with CeO2 nanoparticles was refined and compact granular crystalline. The wear mechanisms of the coatings were investigated from the worn surface of the coatings, wear debris, and the worn surface of the counter-body balls. The wear mechanisms of the coatings without CeO2 included abrasive wear, adhesive wear, and fatigue wear, while the wear mechanisms of the coatings modified with CeO2 nanoparticles included only abrasive wear and adhesive wear, because the fine microstructure of the coatings had an excellent resistance to fatigue wear.

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Review of Antibacterial Activity of Titanium-Based Implants’ Surfaces Fabricated by Micro-Arc Oxidation

Cited by 69 publications

References 111 publications

Antimicrobial Nanostructured Coatings: A Gas Phase Deposition and Magnetron Sputtering Perspective

Antimicrobial Nanostructured Coatings: A Gas Phase Deposition and Magnetron Sputtering Perspective

Chemical and Biological Roles of Zinc in a Porous Titanium Dioxide Layer Formed by Micro-Arc Oxidation

Laser Cladding of Ti-Based Ceramic Coatings on Ti6Al4V Alloy: Effects of CeO2 Nanoparticles Additive on Wear Performance

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