Zirrhotische Kardiomyopathie

Kasper, Philipp; Steffen, Hans‐Michael; Michels, Guido

doi:10.1055/a-1321-9523

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…In addition, there are clinical evidences of an association between the degree of hepatic insufficiency and the severity of cardiomyopathy due to cirrhosis. A recent study on advanced cirrhosis pointed out an association between the degree of CCM and Model for End-Stage Liver Disease (MELD) scores 41 , 42 . Hepatocellular injury and elevated levels of various serological markers such as ALT, AST, TNF-α, YKL-40 (related to liver injury and inflammation) exacerbate hemodynamic disturbances and hyperdynamic circulation which further aggravate myocardial injury 13 , 35 , 43 .…”

Section: Discussionmentioning

confidence: 99%

Myocardial injury is a risk factor for 6-week mortality in liver cirrhosis associated esophagogastric variceal bleeding

Liu

Ding

et al. 2023

Sci Rep

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This study sought to investigate risk factors for 6-week mortality of patients with decompensated liver cirrhosis associated esophagogastric variceal bleeding (EGVB) and clinical characteristics of myocardial injury in cirrhotic patients with EGVB. This retrospective cohort study included 249 patients with decompensated liver cirrhosis associated EGVB in the Department of Emergency. Patients were divided into two groups including liver cirrhosis associated EGVB without myocardial injury and liver cirrhosis associated EGVB with myocardial injury. Myocardial injury, recurrent bleeding, total bilirubin (TBIL) level and dyslipidemia are independent risk factors for 6-week mortality in liver cirrhosis associated EGVB. Among all patients with liver cirrhosis associated EGVB, 90 (36.2%) had myocardial injury and 159 individuals (63.8%) not. The 6-week mortality in the group with myocardial injury was 21%, which was significantly higher than that of 7% in the group without myocardial injury. More patients in the myocardial injury group smoked, had moderate to severe esophageal varices, liver failure, and Child–Pugh C liver function compared to the non-myocardial injury group. Myocardial injury, recurrent bleeding, TBIL level and dyslipidemia are independent risk factors for death within 6 weeks in liver cirrhosis associated EGVB. The 6-week mortality is considerably higher in patients with myocardial injury in liver cirrhosis associated EGVB than those without myocardial injury.

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Section: Discussionmentioning

confidence: 99%

Myocardial injury is a risk factor for 6-week mortality in liver cirrhosis associated esophagogastric variceal bleeding

Liu

Ding

et al. 2023

Sci Rep

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The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice

Zhang

Wang

Liu

et al. 2022

BioMed Research International

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Heart failure is currently one of the leading causes of death worldwide, and the inflammatory factors play an important role in its development. Chitosan oligosaccharide (COS), a low-molecular-weight form of chitosan, has many specific biological activities. In this study, COS effects on heart failure were studied for the first time by performing transverse arch constriction (TAC) surgery in mice, as an animal model of heart failure. Our findings revealed that COS administration (in both 40 mg/kg and 80 mg/kg doses) significantly ameliorated TCA-induced left ventricular (LV) hypertrophy as well as the increase in lung and heart weight in mice, while improving TAC-induced LV dysfunction. Both doses effectively attenuated LV cardiomyocyte hypertrophy, while decreasing heart inflammation after heart failure in mice. In conclusion, our results indicated that the supplementation of COS in normal diet might be an effective way to prevent further myocardial tissue damage in patients suffering from heart failure.

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Zirrhotische Kardiomyopathie

Cited by 2 publications

References 20 publications

Myocardial injury is a risk factor for 6-week mortality in liver cirrhosis associated esophagogastric variceal bleeding

Myocardial injury is a risk factor for 6-week mortality in liver cirrhosis associated esophagogastric variceal bleeding

The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice

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