Zinquin Ester—a Reagent for the Investigation of the Role of Available ZN(II) in Living Systems

Ward, David D.; Lincoln, Stephen F.; Betts, Henry B.; Zalewski, Peter D.; Forbes, Ian J.; Mahadevan, I. B.; Kimber, Marc C.; Hendrickson, Kym M.

doi:10.1007/0-306-47466-2_307

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Introduction1

Insight Into Zinc Functions In An Organism1

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2003

2024

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Cited by 4 publications

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“…Zinquin binds Zn with dissociation constants in the nanomolar range, giving a stable signal in intact cells, as well as in frozen tissues 16,17 . We have developed a sensitive Zinquin‐based assay to measure labile Zn in plasma and, in this study, have used that assay to measure Zn in sputum 18,19 . Labile and total sputum [Zn] concentrations were compared with those in plasma, in subjects with or without asthma.…”

Section: Introductionmentioning

confidence: 99%

Sputum zinc concentration and clinical outcome in older asthmatics

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Sputum zinc concentration and clinical outcome in older asthmatics

et al. 2011

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“…In cells zinc is localized in membranous organelles (vesicles, Golgi apparatus). Its excessive release from such reserves threatens cytoplasmic enzymes its toxicity (Ward et al, 2000). Ligands-chelators (Frederickson, 2003), ionophores (Ho et al, 2004;Ding et al, 2008Ding et al, , 2009 are used to bind the excessive labile zinc.…”

Section: Insight Into Zinc Functions In An Organismmentioning

confidence: 99%

Role of Zinc in an Organism and Its Influence on Processes Leading to Apoptosis

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2011

BJMMR

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This review brings together and analyzes the problem of zinc effects on the body through apoptosis, also affecting the latest data in the study of process itself apoptosis. Also, the possibility of using zinc and its derivatives and its complexes in cancer treatment are discussed. The review also focuses on the biochemical problems that lead to various diseases occurring in conditions of excess or deficiency of intracellular zinc. Review includes more than 300 references and contains research over the past ~ 15 years, focusing on the latest data.

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