Zingiber officinale : Its antibacterial activity on Pseudomonas aeruginosa and mode of action evaluated by flow cytometry

Chakotiya, Ankita Singh; Tanwar, Ankit; Narula, Alka; Sharma, Rakesh Kumar

doi:10.1016/j.micpath.2017.03.029

Cited by 52 publications

(36 citation statements)

References 14 publications

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“…The antibacterial activity of BTS is one possible mechanism. Among BTS components, Menthae Herba, Zingiberis Rhizoma, Rhei Rhizoma, Paeoniae Radix, Atractylodis Rhizoma, and Forsythia Fruit are reported to possess antibacterial activity [41][42][43][44][45][46][47][48]. Here, the total number of bacteria was estimated by qPCR to assess the possible influence of BTS on bacterial count.…”

Section: Discussionmentioning

confidence: 99%

Increase of Akkermansia muciniphila by a Diet Containing Japanese Traditional Medicine Bofutsushosan in a Mouse Model of Non-Alcoholic Fatty Liver Disease

et al. 2020

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Non-alcoholic fatty liver disease (NAFLD) is considered a worldwide healthcare problem that mirrors the increased prevalence of obesity. Gut microbiota plays a crucial role in the progression and treatment of NAFLD. Bofutsushosan (BTS), a pharmaceutical-grade Japanese traditional medicine, has long been prescribed in Japan for obesity and obesity-related syndrome. Although BTS has been reported to exert an anti-obesity effect in obese patients as well as various obesity-model animals, its effect on gut microbiota is unknown. Here, the effects of BTS on obesity, liver damage, and the gut microbiome in genetically obese mice, ob/ob, were studied. Seven-week-old ob/ob mice were fed a standard diet with (BTS group) or without (CONT group) 5% BTS for 4 weeks. By comparison to the CONT group, the BTS group showed reduced body weight gain and hyperlipidemia as well as improved liver function. Moreover, gut microbiota in the CONT and BTS group formed a significantly different cluster. Specifically, the genera Akkermansia, Bacteroides and an unknown genus of the family Enterobacteriaceae expanded dramatically in the BTS group. Noteworthy, the population of Akkermansia muciniphila, which is reported to elicit an anti-obesity effect and improve various metabolic abnormalities, was markedly increased (93-fold) compared with the CONT group. These results imply that BTS may be a promising agent for treating NAFLD.

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Section: Discussionmentioning

confidence: 99%

Increase of Akkermansia muciniphila by a Diet Containing Japanese Traditional Medicine Bofutsushosan in a Mouse Model of Non-Alcoholic Fatty Liver Disease

et al. 2020

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“…Disk and well diffusion agar DMSO [16] Broth microdilution MIC and MBC DMSO 5% [21] MIC-diffusion agar Ethanol [29] Agar disk diffusion Acetone [30] MIC-broth microdilution Ginger essential oil [31] Agar disk diffusion Essential oil [32] MIC-broth microdilution Tween 80 [33] Agar disk diffusion Ginger essential oil [34] MIC-broth microdilution Tween 126 [35] Agar-agar diffusion DMSO [36] Broth microdilution MIC and MBC DMSO [37] DMSO, dimethyl sulfoxide; MIC, minimum inhibitory concentration; MBC, minimum bactericidal concentration. constitution of the Gram-negative cell wall [16], although the effect of high sensitivity on Gram-negative strains such as K. pneumonia has been observed [39].…”

Section: Methods Dilution Referencementioning

confidence: 99%

“…However, the use of several methods to determine antimicrobial activity, as verified in [16], can directly interfere with the result. Although interference of chemical composition is possible, the MIC values found in several studies do not demonstrate a reproducibility using broth dilutions [21,31,33,35,37].…”

Section: Antimicrobial Assays With Gingermentioning

confidence: 95%

“…As can be seen in Table 2, there is no standardization of ginger oil dilution, which can lead to uncertain results as it is an oil, and, because it is a less dense material than water, the oil cannot be diluted directly in the broth, which limits their miscibility in the test media. Therefore, a surfactant should be added, and we found that the most commonly used was DMSO [16,21,36,37], tween [33,35], some solvents like ethanol [29] and acetone [30], and even ginger oil [31,32,34]. The disk diffusion and well diffusion tests have been used to evidence antimicrobial activities, assuming that all components of the oil have the same solubility, but as verified in Tables 3 and 4, the diffusion of oil in the agar, during the test, may not diffuse into the agar, limiting the use of this method.…”

Section: Antimicrobial Assays With Gingermentioning

confidence: 99%

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Ginger (Zingiber officinale) Antimicrobial Potential: A Review

Teles¹,

Santos²,

Ferreira³

et al. 2020

Ginger Cultivation and Its Antimicrobial and Pharmacological Potentials

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Zingiber officinale Roscoe, commonly known as gengibre, ajengibre, jengibre dulce (Brazil, Argentina, and Spain), ginger (United States and England), and gingembre (France), is a perennial herbaceous plant that produces a fleshy and articulated rhizome, with rough brownish epidermis. As a medicinal plant, ginger is one of the oldest and most popular in the world. Several properties of the ginger have been verified in scientific experiments, with emphasis to the antimicrobial activity. Ginger essence oil has been investigated by several in vitro microbiological techniques, in which most of its essential oils presented antimicrobial activity against all selected bacteria. The antimicrobial effect is attributed mainly to several phytochemicals, such as camphene, phellandrene, zingiberene, and zingerone. This review provides an overview of the experimental evidence for the antimicrobial potential of Z. officinale.

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“…After decades of endeavors, scientists have found that flavonoids possess a wide variety of biological and pharmacological properties, which leads to numerous studies on these secondary metabolites. These health-beneficial properties include antiangiogenic [22], antibacterial [23][24][25][26][27] [67], leishmanicidal [68], neuroprotective [69], photoprotective [43], and trypanocidal activities [68,70]. In addition, the flavonoids can inhibit eukaryotic protein synthesis [71] and a variety of important enzymes such as aggrecanase [72], aldose reductase [30,73], alpha-glucosidase [60], cholinesterase [26,74], protein tyrosine phosphatase and acetylcholinesterase [75], and tyrosinase [44,64].…”

Section: Classification and Biological Activities Of Flavonoidsmentioning

confidence: 99%

Flavonoids and Pectins

Zhang¹,

He²,

Zhang³

2020

Pectins - Extraction, Purification, Characterization and Applications

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Pectins and flavonoids are two related groups of important secondary metabolites derived from plants. The interaction between pectins and flavonoids can affect their shelf-life stability, functionality, bioavailability, and bioaccessibility. In this chapter, we will concentrate on the current opinions on the flavonoids to understand how to classify this group of secondary metabolites, what biological and pharmacological activities they possess, and how to biosynthesize them in plants. We will then discuss the general strategies for the derivation of these small secondary compounds. The strategies comprise traditional plant extraction, chemical synthesis, and biosynthesis. We will also discuss the advantages and disadvantages of these three production strategies in the derivation of flavonoids and the future research directions in generating health-beneficial flavonoids using the biosynthetic strategy.

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Zingiber officinale : Its antibacterial activity on Pseudomonas aeruginosa and mode of action evaluated by flow cytometry

Cited by 52 publications

References 14 publications

Increase of Akkermansia muciniphila by a Diet Containing Japanese Traditional Medicine Bofutsushosan in a Mouse Model of Non-Alcoholic Fatty Liver Disease

Increase of Akkermansia muciniphila by a Diet Containing Japanese Traditional Medicine Bofutsushosan in a Mouse Model of Non-Alcoholic Fatty Liver Disease

Ginger (Zingiber officinale) Antimicrobial Potential: A Review

Flavonoids and Pectins

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