Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge

Abstract

Zingiber mioga (Thunb.) Roscoe (ZM) is a traditional medicine, used to treat inflammatory diseases. The present study aimed to evaluate the inhibitory effects of ZM on the inflammatory response in lipopolysaccharide (LPS)‑stimulated RAW264.7 murine macrophage cells and in a mouse model of ovalbumin (OVA)‑induced allergic asthma. Mice received OVA sensitization on day 0 and 14, and were challenged with OVA between days 21 and 23. ZM was administered to the mice at a dose of 30 mg/kg, 1 h prior to OVA challenge. In LPS‑stimulated RAW264.7 cells, ZM significantly decreased nitric oxide (NO) and tumor necrosis factor (TNF)‑α production in a concentration‑dependent manner, and mRNA expression of inducible NO synthase (iNOS), TNF‑α and matrix metalloproteinase (MMP)‑9 was reduced. In addition, treatment with ZM decreased the inflammatory cell count in bronchoalveolar lavage fluid from the mice, and reduced the expression of interleukin (IL)‑4, IL‑5, IL‑13, eotaxin and immunoglobulin E. ZM also reduced airway hyperresponsiveness in OVA‑challenged mice, and attenuated the infiltration of inflammatory cells and mucus production in the airways, with a decrease in the expression of iNOS and MMP‑9 in lung tissue. In conclusion, the results of the present study indicate that ZM effectively inhibits inflammatory responses. Therefore, it may be that ZM has potential as a therapeutic agent for use in inflammatory diseases.

Major Bioactive Compounds in Essential Oils Extracted From the Rhizomes of Zingiber zerumbet (L) Smith: A Mini-Review on the Anti-allergic and Immunomodulatory Properties

“…Currently, there are only a few zingiber genus that have been reported to contain anti-allergic properties, including Z. officinale , Z. cassumunar , Z. zerumbet , and Z. mioga ( Tewtrakul and Subhadhirasakul, 2007 ; Shin et al, 2015 ). The major bioactive compounds which can be found in the essential oil of Z. officinale are α-zingiberene (17.4–32.2%), β-sesquiphellandrene (6.6–27.16%), and geranial (25.9%); for Z. cassumunar is sabinene (36.71–53.50%); for Z. zerumbet are zerumbone (35.5–84.8%) and pinene (10.3% to 31.4%); for Z. mioga is β-phellandrene (26.60%) ( Kurobayashi et al, 1991 ; Sharifi-Rad et al, 2017 ).…”

Synergistic lipid‑lowering effects of Zingiber mioga and Hippophae rhamnoides extracts

“…Zingiber mioga (of the Zingiberaceae family) is grown in Korea and Japan, where its flower buds are eaten as pickles, in salads and brochettes. It has been suggested to exhibit diverse biological functions, including antihyperglycemic and antioxidant activity, and to improve allergic asthma and memory (16)(17)(18). A previous study by our research group demonstrated that Zingiber mioga extract (ZM) exerted an anti-obesity effect in HFD-induced obese mice, and revealed the effects of ZM on insulin resistance and liver gluconeogenesis (19); however, only a high concentration of ZM showed a significant effect in these previous experiments.…”