2016
DOI: 10.3892/etm.2016.3331
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Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice

Abstract: Abstract. Zingiber mioga is a perennial herb belonging to the ginger family (Zingiberaceae) that is used medicinally to treat cough and rheumatism in China and consumed throughout Japan. The aim of the present study was to investigate the anti-obesity effects of Z. mioga following extraction with distilled water or 70% ethanol. In 3T3-L1 preadipocyte cells, Z. mioga water extract (ZMW) markedly inhibited adipogenesis, whereas the ethanol extract had no effect. In addition, we conducted ZMW feeding experiments … Show more

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Cited by 11 publications
(10 citation statements)
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“…In the present study, the inhibitory effects of the ZH mixture on lipid accumulation in vitro were examined and its anti-obesity effects in HFD-induced obese mice evaluated. The results indicated that treatment with individual extracts inhibited lipid accumulation in 3T3-L1 adipocytes, as shown in previous studies (19,25). This effect was found to be higher than predicted (using the equation proposed by Colby (29) following treatment with a mixture containing both materials.…”
Section: Discussionsupporting
confidence: 84%
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“…In the present study, the inhibitory effects of the ZH mixture on lipid accumulation in vitro were examined and its anti-obesity effects in HFD-induced obese mice evaluated. The results indicated that treatment with individual extracts inhibited lipid accumulation in 3T3-L1 adipocytes, as shown in previous studies (19,25). This effect was found to be higher than predicted (using the equation proposed by Colby (29) following treatment with a mixture containing both materials.…”
Section: Discussionsupporting
confidence: 84%
“…Specifically, PPAR and C/EBPα are transcription factors that induce the expression of several genes involved in adipogenic differentiation (40). Previous studies have shown that ZM and HR inhibit fat accumulation by suppressing the expression of these genes (19,26). The results of the present study indicated that ZH treatment inhibited the expression of genes related to adipocyte differentiation in 3T3-L1 cells to a degree greater than that observed following treatment with either single extract.…”
Section: Discussionsupporting
confidence: 48%
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“…(Zingiber mioga) is a Zingiberaceae family from China, Japan, and Korea. Its young flower buds and fruit has been used as a traditional food (Jo et al 2016), and it is used medicinally to treat the irregular menstruation, dysmenorrhea, cough, and asthma in China and consumed throughout Japan (Huang et al 2016;Lee et al 2016;. Moreover, Zingiber mioga also has important medical and natural pigment value (Huang and Li 2013;Huang et al 2016).…”
mentioning
confidence: 99%
“…After a 15-hour fast (5:00 pm-8:00 am), the mice were injected intraperitoneally with glucose (2 g/kg of body weight). The blood glucose levels at 0, 15, 30, 60, and 120 min were measured using an accurate blood glucose meter (Accu-check Performa, Roche, Germany) [15][16][17][18]. The area under the curve (AUC) was calculated using the trapezoid rule.…”
Section: Intraperitoneal Glucose Tolerance Test (Ipgtt)mentioning
confidence: 99%