Zinc transporter 8 autoantibodies in patients with type 1 diabetes from a multiethnic population and their first degree relatives

Araújo, Dorothy Sue Dunn de; Skärstrand, Hanna; Barone, Bianca; Dantas, Joana Rodrigues; Kupfer, Rosane; Zajdenverg, Lenita; Milech, Adolpho; Vaziri-Sani, Fariba; Oliveira, José Egídio Paulo de; Rodacki, Melanie

doi:10.1590/0004-2730000003088

Cited by 7 publications

(8 citation statements)

References 31 publications

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“…In the present study, neither presence nor levels of ZnT8A were found to be related to BMI, a finding similar to some previous reports ( 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ). Conversely, there are reports indicating that ZnT8A positivity is more frequent in the leaner T1D patients than in the more obese, but it was mentioned that larger cohorts were necessary to verify this negative association ( 17 ).…”

Section: Discussionsupporting

confidence: 92%

“…However, in another Asian population, Japanese acute onset T1D patients (19.1±14.5 years old) had 58% ZnT8A positivity, which is very similar to our findings in a Turkish population ( 22 ). A study from Brazil, which encompassed both a Caucasian and a non-Caucasian new onset T1D population (30.3±11.4 years old), found an overall ZnT8A positivity of 24% and it was stated that neither ZnT8A positivity nor concentration was associated with ethnicity ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 Diabetes

Elmaoğulları

Uçaktürk

Elbeğ

et al. 2018

Jcrpe

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Objective:Zinc transporter 8 protein (ZnT8A) is a transmembrane protein which functions to transfer zinc to insulin vesicles. Antibodies formed against ZnT8A (ZnT8A) are regarded as an independent autoimmunity demonstrator in type 1 diabetes (T1D). The aim of this study was to investigate the prevalence of ZnT8A in Turkish children with new onset T1D.Method:Eighty four patients between 1-18 years of age diagnosed with T1D between February 2015-March 2016 and the control group consisting of 50 healthy children without any autoimmune diseases were included in the study. Serum samples for ZnT8A testing were taken from the patient group within a week of diagnosis. A ZnT8A enzyme-linked immunosorbent assay was used in the analyses.Results:ZnT8A positivity was detected in 58% of the patients with new onset T1D and 8% of the control group. ZnT8A were demonstrated in 5 of 11 patients with negative results for classical diabetes antibodies [insulinoma antigen-2 antibody (IA-2A), glutamic acid decarboxylase (GAD) or insulin autoantibodies]. No association was found between ZnT8A positivity and age, gender, presence or degree of ketoacidosis at presentation, hemoglobin A1c, insulin or C-peptide concentration, or the presence of either thyroid or celiac antibodies.Conclusion:ZnT8A prevalence in children with T1D in Turkey was compatible with the literature. The ratio of patients who are clinically considered to have T1D but have negative routine diabetes auto-antibodies were observed to decrease nearly by 50% when ZnT8 antibodies were added to the panel. ZnT8 measurement should be more widespread for clarifying the etiology in T1D.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 Diabetes

Elmaoğulları

Uçaktürk

Elbeğ

et al. 2018

Jcrpe

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“…14) A study from Brazil, which encompassed both a Caucasian and a non-Caucasian new onset T1D population (30.3±11.4 years old), found an overall ZnT8A positivity of 24% and it was stated that neither ZnT8A positivity nor concentration was associated with ethnicity. 15) The differences in prevalence of various types of islet autoantibodies among different ethnic populations with T1D could be explained by genetic factors especially HLA genotypes and SLC30A8 gene polymorphism. 4,5) Additionally, a recent international prospective cohort study identified a number of non-HLA genes as genetic factors for development of islet autoimmunity and T1D.…”

Section: Discussionmentioning

confidence: 99%

“…However, in another Asian population, Japanese acute onset T1D patients (19.1±14.5 years old) had 58% ZnT8A positivity [ 14 ]. A study from Brazil, which encompassed both a Caucasian and a non-Caucasian new onset T1D population (30.3±11.4 years old), found an overall ZnT8A positivity of 24% and it was stated that neither ZnT8A positivity nor concentration was associated with ethnicity [ 15 ]. The differences in prevalence of various types of islet autoantibodies among different ethnic populations with T1D could be explained by genetic factors especially HLA genotypes and SLC30A8 gene polymorphism [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

Zinc transporter 8 autoantibody in the diagnosis of type 1 diabetes in children

2020

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Background: Type 1 diabetes (T1D) is an organ-specific autoimmune disease related to the autoimmune response against pancreatic β-cells. Zinc transporter 8 (ZnT8), an islet-specific gene product localized to the β-cell insulin granule, was recently identified as an autoantigen in T1D.Purpose: To evaluate the use of ZnT8 autoantibody (ZnT8A) for diagnosing T1D.Methods: This case-control study was conducted at Dr. Soetomo General Hospital, Surabaya, Indonesia, from March to May 2019. Children younger than 18 years of age with T1D based on the International Society for Pediatric and Adolescent Diabetes guideline and healthy controls were included. We measured ZnT8A level using enzyme-linked immunosorbent assay (cutoff value, 0.315).Results: There were 30 children with T1D (50.0% boys; mean age, 11.3±3.7 years) and 18 healthy controls (44.4% boys; mean age, 8.3±3.1 years); 1 patient in each group was Madurese, while the others were Javanese. Twenty-two of 30 subjects with T1D (73.3%) tested positive for ZnT8A compared to 5 of 18 controls (27.8%) (<i>P</i>=0.02; odds ratio, 7.15; 95% confidence interval, 1.93–26.52). When ZnT8A-positive and -negative T1D cases were compared, no differences were detected in age at diagnosis, duration of diabetes, presence of ketoacidosis, body mass index, glycosylated hemoglobin concentration, or C-peptide concentrations.Conclusion: ZnT8A may be useful in the diagnosis of T1D.

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“…In recent years, polymorphisms in the solute carrier family 30 member 8 (SLC30A8) gene (ZnT8) with increased type 1 [175][176][177][178][179][180] and type 2 diabetes [177,[181][182][183][184] susceptibility were found (see also paragraph 2). In fact, a connection between the functionality of SLC30A8 has been observed and zinc concentration in plasma was shown able to influence glucose tolerance [185].…”

Section: Genetic Polymorphisms Involved In Zinc Status and Non Communmentioning

confidence: 99%

Genetic Polymorphisms and Zinc Status: Implications for Supplementation in Metabolic Diseases

Virgili

Ambra

McCormack

et al. 2019

CPD

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Background: Zinc is an essential component for all living organisms, representing the second most abundant trace element, after iron. This element is widely distributed in the tissues of human body where it is involved in the normal growth, reproduction and several biological functions including immunity, energy metabolism and antioxidant processes. Because of its essential role, zinc levels in human body must remain constant, independently of dietary intake fluctuations. The homeostasis of zinc is a well-regulated cellular process and has been reported to be chiefly mediated by the expression and activity of zinc-binding proteins such as metallothioneins and zinc transporters. Genes encoding for these proteins are subjected to genetic variants. Methods: We performed a multi-database electronic search to provide an overview on the relationship between specific polymorphisms (SNP) of genes encoding for metallothioneins and zinc transporters and their relationship with zinc status, immune function and some non-communicable diseases. Results: A number of SNP are implicated in a range of metabolic disease. Some SNP may affect the impact of zinc supplementation on immune function, diabetes, obesity. Conclusion: New studies are needed to clarify the interaction between individual genetic profile and zinc status. Moreover, there is a need to a better interaction between the scientific bodies and health professionals to allow better dietary and behavioural recommendations to promote human health, with particular concern to elderly people.

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Zinc transporter 8 autoantibodies in patients with type 1 diabetes from a multiethnic population and their first degree relatives

Cited by 7 publications

References 31 publications

Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 Diabetes

Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 Diabetes

Zinc transporter 8 autoantibody in the diagnosis of type 1 diabetes in children

Genetic Polymorphisms and Zinc Status: Implications for Supplementation in Metabolic Diseases

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