Zinc therapy for night blindness in cystic fibrosis

Tinley, Christopher; Withers, Nicholas; Sheldon, Christopher; Quinn, Anthony G.; Jackson, Alan A.

doi:10.1016/j.jcf.2007.11.005

Cited by 10 publications

(6 citation statements)

References 15 publications

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“…15 An increase has been observed in the sputum zinc levels in pulmonary exacerbations, and a decrease has been observed in the levels after treatment in bronchiectasis (cystic fibrosis and non-cystic fibrosis bron- chiectasis); however, the significance of this remains unclear. 16 Tinley et al 17 observed an interaction between the serum zinc and vitamin levels. They reported an improvement in the zinc levels after supplementation with retinol.…”

Section: Discussionmentioning

confidence: 98%

Zinc Supplementation for One Year Among Children with Cystic Fibrosis Does Not Decrease Pulmonary Infection

Sharma¹,

Lodha²,

Shastri³

et al. 2015

Respir Care

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BACKGROUND: Children with cystic fibrosis may have a deficiency of micronutrients, including zinc, which may affect their susceptibility to infections. There is a paucity of data on zinc supplementation among children with cystic fibrosis. We hypothesized that a pharmacologic dose of zinc administered daily for 12 months would reduce the need for antibiotics by 50%. METHODS: This double-blind randomized placebo-controlled trial was conducted among children with cystic fibrosis to assess the effect of zinc supplementation on the need for antibiotics and pulmonary function tests. The children, age 5-15 y, of either sex, received either 30-mg zinc tablets or similar looking placebo tablets daily in addition to standard care. They were followed up every month for a period of 12 months and whenever they had pulmonary exacerbations. Their serum zinc was estimated at baseline and at 12 months of enrollment. During each visit, the children underwent a pulmonary function test and sputum culture. RESULTS: Of a total of 43 children screened, 40 were enrolled, and of them, 37 completed the study. The median (interquartile range) number of days of the administration of antibiotics over 12 months of follow-up among the children receiving zinc was 42 (14 -97) d. In the placebo group, it was 38 (15-70) d (P ‫؍‬ .79). There were no significant differences in the percent-of-predicted FEV 1 or change in FEV 1 values at 12 months (P ‫؍‬ .44). The number of children in whose respiratory specimens Pseudomonas was isolated was similar for the 2 groups at different time intervals. The adverse events reported were similar in the 2 groups. CONCLUSION: We did not find any significant difference in the need for antibiotics, pulmonary function tests, hospitalization, colonization with Pseudomonas, or the need for antibiotics for children with cystic fibrosis receiving zinc supplementation of 30 mg/d.

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Section: Discussionmentioning

confidence: 98%

Zinc Supplementation for One Year Among Children with Cystic Fibrosis Does Not Decrease Pulmonary Infection

Sharma¹,

Lodha²,

Shastri³

et al. 2015

Respir Care

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“…Previous case studies have highlighted the importance of zinc in the treatment of night blindness, with one case study using zinc alone to successfully treat it. 10 , 13 This boy's zinc was within the normal range; however, only 0.1% of zinc is located in the serum, so it is a poor indicator of zinc status 14 . Zinc deficiency could have been a cause, but by giving the 6 ADEK tablets per day, we were giving 45 mg of zinc per day and thus treating any zinc deficiency that may have been present…”

Section: Discussionmentioning

confidence: 99%

Night Blindness in a Teenager With Cystic Fibrosis

et al. 2011

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This article describes the case of a 16-year-old boy with cystic fibrosis who presented with difficulty seeing in the dark. He had a history of bowel surgery at birth, and he developed cystic fibrosis liver disease and osteopenia during his teenage years. He always had good lung function. When his serum vitamin A level was checked, it was undetectable in sample. He was diagnosed with night blindness and commenced on high-dose vitamin A. His symptoms resolved within 3 days. However, it took over 1 year for his vitamin A level to return to normal. This case emphasizes the importance of monitoring vitamin levels in cystic fibrosis to detect deficiency and prevent long-term consequences, and it highlights the challenges encountered during the course of night blindness treatment.

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“…17 Zinc supplementation alone led to resolution of nyctalopia in a patient with cystic fibrosis with combined zinc and vitamin A deficiency. 18 ERG rod responses improved dramatically after zinc supplementation. ERG characteristics of zinc deficiency include diminished scotopic A-and B-wave amplitudes; B-wave amplitudes may be affected to a greater degree.…”

Section: Zinc Deficiency and Retinal Physiologic Manifestationsmentioning

confidence: 91%