Zinc supplementation promotes oocyte maturation and subsequent embryonic development in sheep

Yao, Yupei; Tang, Yujie; Qin, Haoqiang; Ru, Meng; Zhang, Chengtu; Zhang, Yingbin; Qiao, Peipei; Li, Jun; Su, Jianmin

doi:10.1016/j.theriogenology.2023.04.025

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Zinc plays an integral role in oocyte maturation, quality, and functionality, serving as a pivotal element in various cellular and metabolic pathways crucial for the oocyte's proper development and maturation [208,209]. It acts as a crucial cofactor for enzymes like DNA polymerase [210], ribonucleotide reductase [211], and thymidylate synthase [212], vital for DNA synthesis and repair [213,214].…”

Section: Zincmentioning

confidence: 99%

“…Insulin metabolism [105] Steroid synthesis [39,40] Hormone Balance [37] Regulation of LH and FSH [38] Ovulation [219] Oocyte maturation [208,209], development [228], and quality [226] Antioxidant properties [264,269], protect embryos from ROS [43,44], and modulate inflammation in endometriosis [281,368] Cellular proliferation and differentiation in the endometrium [56], neutralizes alterations [279] and deficiency correlates with endometrial cysts and polyps [47,48] Mg Cofactor for the production and function of estrogen [163,164], stabilizing glucose metabolism [174] and disbalances are associated with PCOS [165,166,168] Mg deficiency leads to oxidative stress [327,329,330]. Magnesium can preserve the quality of the oocyte [251,327], modulate the ovulation process [338], and contribute to the healthy functioning of the endometrium [337].…”

Section: Znmentioning

confidence: 99%

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Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

Kapper,

Oppelt,

Ganhör

et al. 2024

Nutrients

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The role of minerals in female fertility, particularly in relation to the menstrual cycle, presents a complex area of study that underscores the interplay between nutrition and reproductive health. This narrative review aims to elucidate the impacts of minerals on key aspects of the reproductive system: hormonal regulation, ovarian function and ovulation, endometrial health, and oxidative stress. Despite the attention given to specific micronutrients in relation to reproductive disorders, there is a noticeable absence of a comprehensive review focusing on the impact of minerals throughout the menstrual cycle on female fertility. This narrative review aims to address this gap by examining the influence of minerals on reproductive health. Each mineral’s contribution is explored in detail to provide a clearer picture of its importance in supporting female fertility. This comprehensive analysis not only enhances our knowledge of reproductive health but also offers clinicians valuable insights into potential therapeutic strategies and the recommended intake of minerals to promote female reproductive well-being, considering the menstrual cycle. This review stands as the first to offer such a detailed examination of minerals in the context of the menstrual cycle, aiming to elevate the understanding of their critical role in female fertility and reproductive health.

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Section: Zincmentioning

confidence: 99%

Section: Znmentioning

confidence: 99%

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

Kapper,

Oppelt,

Ganhör

et al. 2024

Nutrients

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“… 2013 ) and consequently normal ovarian functions (Yao et al. 2023 ). The mechanism of Zn metabolism in both males and females is based on interactions between Zn and sexual hormone receptors (Hojyo and Fukada 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Zinc-nanoparticles alleviate the ovarian damage induced by bacterial lipopolysaccharide (LPS) in pregnant rats and their fetuses

El-Beltagy,

Bakr,

Mekhaimer

et al. 2023

Histochem Cell Biol

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Lipopolysaccharide (LPS) is an endotoxin derived from the cell wall of Gram-negative bacteria. LPS exposure during early gestation is associated with adverse effects on the placenta as well as on developmental outcomes, including embryonic resorption, fetal death, congenital teratogenesis, and fetal growth retardation. This work aimed to explore the adverse effects of LPS injected at an early stage of gestation on the gonads of pregnant rats and the ovaries of their pups and the role of zinc nanoparticles (Zn-NPs) against these adverse effects. Twenty-four pregnant rats were used in this study. They were divided at gestation day 4 into four groups (n = 6): control, Zn-NPs (20 mg/kg orally from gestation day E14 till the end of weaning), LPS (50 µg/kg at gestation days E7 and E9), and LPS + Zn-NPs group. The body weight and placenta weight were recorded at gestational day 16. At postnatal day 21 (weaning), the mothers rats and their offspring were sacrificed and immediately dissected to remove the ovaries and uteri from the mothers and the ovaries from their offspring for subsequent biochemical, histological, and immunohistochemical investigations. The obtained results revealed that LPS exposure during early gestation caused severe histopathological alterations in the placenta, uterus, and ovaries of mothers, as well as in the ovaries of their pups. Also, the uterine and ovarian sections displayed a positive reaction for caspase-3 antibody and a negative reaction for Bcl-2 antibody, which reflects the apoptotic effect of LPS. Additionally, remarkable reductions in the levels of antioxidants (superoxide dismutase and catalase) and significant increases in malondialdehyde (MDA) levels were recorded in the serum of LPS-treated mothers and in the ovarian tissues of their offspring. Further biochemical analysis of the ovarian tissues from LPS-maternally treated offspring showed a significant increase in the levels of caspase-3, TNF-α, and TGF-β1, but a significant decrease in the level of IGF-1. On the other hand, treatment of mothers with Zn-NPs from day 14 of gestation until the weaning day (21st day postnatal) successfully ameliorated most of the deleterious histopathological, immunohistochemical, and biochemical changes induced by LPS. Graphical abstract

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