Zinc supplementation combined with antidepressant drugs for treatment of patients with depression: a systematic review and meta-analysis

Silva, Laís Eloy Machado da; Santana, Mônica Leila Portela de; Costa, Priscila Ribas de Farias; Pereira, Érika Sales Joviano; Nepomuceno, Carina Márcia Magalhães; Queiroz, Valterlinda Alves de Oliveira; Oliveira, Lucivalda Pereira Magalhães de; Conceição‐Machado, Maria Ester Pereira da; Sena, Eduardo Pondé de

doi:10.1093/nutrit/nuaa039

Cited by 38 publications

(33 citation statements)

References 46 publications

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“…Last, legumes are rich in micronutrients, especially zinc, which is another micronutrient related to depression (38,39) . In a recent meta-analysis, zinc supplementation was demonstrated as an effective adjunct therapy to anti-depressant medication (40,41) .…”

Section: Discussionmentioning

confidence: 99%

A healthy eating score is inversely associated with depression in older adults: results from the Chilean National Health Survey 2016–2017

Lanuza

Petermann-Rocha

Celis-Morales

et al. 2021

Public Health Nutr.

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Objective: To investigate the relationship of a healthy eating score with depression in Chilean older adults. Design: Cross-sectional study. Setting: Chilean older adults from the Chilean National Health Survey 2016-2017. Associations were analyzed using complex samples multivariable logistic regressions adjusted for: age, sex, socio-demographic, lifestyles (physical activity, smoking, alcohol consumption, and sleep duration), body mass index, and clinical conditions (hypertension, diabetes, hypercholesterolemia, and cardiovascular diseases). Participants: The number of participants were 2,031(≥60y). The Composite International Diagnostic Interview-Short Form (CIDI-SF) was applied to establish the diagnosis of major depressive episode (MDE). Six healthy eating habits were considered to produce the healthy eating score (range: 0-12): consumption of seafood, whole grain, dairy, fruits, vegetables, and legumes. Participants were categorized according to their final scores as healthy (≥9), average (5 to 8), and unhealthy (≤4). Results: Participants with a healthy score had a higher educational level, physical activity, and regular sleep hours than participants with an average and unhealthiest healthy eating score. Participants classified in the healthiest healthy eating score had an inverse association with depression (OR: 0.28, 95%CI: 0.10-0.74). Food items that contributed the most to this association were legumes (15.2%) and seafood (12.7%). Conclusion: Participants classified in the healthiest healthy eating score, characterized by a high consumption of legumes and seafood, showed a lower risk for depression in a representative sample of Chilean population.

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Section: Discussionmentioning

confidence: 99%

A healthy eating score is inversely associated with depression in older adults: results from the Chilean National Health Survey 2016–2017

Lanuza

Petermann-Rocha

Celis-Morales

et al. 2021

Public Health Nutr.

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“…Dietary zinc supplements have found numerous applications in human health. Being safe, they have been shown to improve neonatal brain development 43 , sleep quality in adults 42 , and to ameliorate health conditions in depression 39 , epilepsy 40 , and a set psychiatric and neurodegenerative states 41 . For example, daily 25mg Zn 2+ applied for 6 weeks in one study 47 , and daily 220mg zinc sulphate (providing 50mg zinc) applied for 12 days in another 48 , was found to positively act on depression patients.…”

Section: Discussionmentioning

confidence: 99%

“…Dietary zinc supplementation has been applied to treat various human health conditions, including the neurological ones such as depression 39 , epilepsy 40 , psychiatric and neurodegenerative diseases 41 , or sleep disorders 42 , as well as for normal neonatal development 43 . We thus wondered if dietary supplementation of zinc in the Drosophila model of GNAO1 encephalopathy may reveal any bene cial effects.…”

Section: Zpt Restores Cellular Rgs19 Interactions Of Gnao1 Encephalopathy Mutantsmentioning

confidence: 99%

Restoration of the GTPase activity of Gαo mutants by Zn2+ in GNAO1 encephalopathy models

Larasati¹,

Savitsky²,

Koval³

et al. 2021

Preprint

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GNAO1 encephalopathy is a rare pediatric disease characterized by motor dysfunction, developmental delay, and epileptic seizures1-3. De novo point mutations in the gene encoding Gαo, the major neuronal G protein, lie at the core of this dominant genetic malady4. Half of the clinical case mutations fall on codons Gly203, Arg209, or Glu246 near the GTP binding/hydrolysis pocket of Gαo1-3. We here show that these pathologic mutations strongly speed up GTP uptake and inactivate GTP hydrolysis by Gαo, resulting in constitutive GTP binding by the G protein. Molecular dynamics simulations indicate that the mutations cause displacement of Gln205, the key to GTP hydrolysis. Decreased interactions with cellular partners including RGS19 suggest that despite the enhanced GTP residence, the mutants fail to fully adopt the activated conformation and thus transmit the signal. Through a high-throughput screening of approved drugs aiming at correction of this core biochemical dysfunction, we identify zinc pyrithione and Zn2+ ions as agents restoring the active conformation, GTPase activity, and cellular interactions of the encephalopathy mutants, with a negligible effect on wild type Gαo. We describe a Drosophila model of GNAO1 encephalopathy and show that dietary zinc supplementation restores the motor function and longevity of the mutant flies. With zinc supplements frequently recommended for diverse human neurological conditions, our work spanning from identification of the core biochemical defect in Gαo mutants and cellular interactions analysis to high-throughput screening and animal validation of the deficiency-correcting drug defines the potential therapy for GNAO1 encephalopathy patients.

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“…The intake led to a reduction in scores related to anger, depression and discouragement along with an increase in serum zinc; these changes were not seen in the placebo group [ 256 ]. Accordingly, the general population with MDD could also obtain advantages, since the research review of patients treated with antidepressants plus supplementation versus placebo concluded that there was better response and recovery for those treated with this trace element [ 257 ]. Selenium is also a vital molecule for our body; the proper dose of it, along with other nutrients, can have a moderate impact on rectifying the development of TDM [ 258 ].…”

Section: Nutritional Intervention In Women With Mddmentioning

confidence: 99%

The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

et al. 2022

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Major depressive disorder (MDD) is an incapacitating condition characterized by loss of interest, anhedonia and low mood, which affects almost 4% of people worldwide. With rising prevalence, it is considered a public health issue that affects economic productivity and heavily increases health costs alone or as a comorbidity for other pandemic non-communicable diseases (such as obesity, cardiovascular disease, diabetes, inflammatory bowel diseases, etc.). What is even more noteworthy is the double number of women suffering from MDD compared to men. In fact, this sex-related ratio has been contemplated since men and women have different sexual hormone oscillations, where women meet significant changes depending on the age range and moment of life (menstruation, premenstruation, pregnancy, postpartum, menopause…), which seem to be associated with susceptibility to depressive symptoms. For instance, a decreased estrogen level promotes decreased activation of serotonin transporters. Nevertheless, sexual hormones are not the only triggers that alter neurotransmission of monoamines and other neuropeptides. Actually, different dietary habits and/or nutritional requirements for specific moments of life severely affect MDD pathophysiology in women. In this context, the present review aims to descriptively collect information regarding the role of malnutrition in MDD onset and course, focusing on female patient and especially macro- and micronutrient deficiencies (amino acids, ω3 polyunsaturated fatty acids (ω3 PUFAs), folate, vitamin B12, vitamin D, minerals…), besides providing evidence for future nutritional intervention programs with a sex-gender perspective that hopefully improves mental health and quality of life in women.

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Zinc supplementation combined with antidepressant drugs for treatment of patients with depression: a systematic review and meta-analysis

Cited by 38 publications

References 46 publications

A healthy eating score is inversely associated with depression in older adults: results from the Chilean National Health Survey 2016–2017

A healthy eating score is inversely associated with depression in older adults: results from the Chilean National Health Survey 2016–2017

Restoration of the GTPase activity of Gαo mutants by Zn2+ in GNAO1 encephalopathy models

The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

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