The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

García-Montero, Cielo; Ortega, Miguel Á.; Álvarez-Mon, Melchor; Fraile-Martínez, Óscar; Romero-Bazán, Adoración; Lahera, Guillermo; Montes-Rodríguez, José Manuel; Molina-Ruiz, Rosa M.; Mora, Fernando A. Lázaro; Rodríguez‐Jiménez, Roberto; Quintero, Javier; Álvarez‐Mon, Melchor

doi:10.3390/nu14051107

Cited by 16 publications

(12 citation statements)

References 315 publications

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“…However, the global burden of MDD has been increasing during the last years, specially due to the coronavirus disease 2019 (COVID-19) pandemic ( 4 ). Likewise, the risk for suffering from MDD is 2-fold higher in woman than in men, showing some particularities in the underpinning biological mechanisms ( 5 ), and although the prevalence may vary across ages, this condition may appear virtually at any stage of life ( 6 ). Furthermore, MDD entails devastating individual and socioeconomic consequences.…”

Section: Introductionmentioning

confidence: 99%

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

et al. 2022

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Major depressive disorder (MDD) is a complex, multifactorial disorder of rising prevalence and incidence worldwide. Nearly, 280 million of people suffer from this leading cause of disability in the world. Moreover, patients with this condition are frequently co-affected by essential nutrient deficiency. The typical scene with stress and hustle in developed countries tends to be accompanied by eating disorders implying overnutrition from high-carbohydrates and high-fat diets with low micronutrients intake. In fact, currently, coronavirus disease 2019 (COVID-19) pandemic has drawn more attention to this underdiagnosed condition, besides the importance of the nutritional status in shaping immunomodulation, in which minerals, vitamins, or omega 3 polyunsaturated fatty acids (ω-3 PUFA) play an important role. The awareness of nutritional assessment is greater and greater in the patients with depression since antidepressant treatments have such a significant probability of failing. As diet is considered a crucial environmental factor, underlying epigenetic mechanisms that experience an adaptation or consequence on their signaling and expression mechanisms are reviewed. In this study, we included metabolic changes derived from an impairment in cellular processes due to lacking some essential nutrients in diet and therefore in the organism. Finally, aspects related to nutritional interventions and recommendations are also addressed.

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Section: Introductionmentioning

confidence: 99%

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

et al. 2022

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“…Among the elderly, malnourished subjects were 31% more likely to have symptoms of depression than those with normal nutritional status[ 32 , 33 ]. Our results showed that nutritional deficiencies are 1.3 times higher in the depression cohort.…”

Section: Discussionmentioning

confidence: 99%

Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis

Haider¹,

Basida²,

Kaur³

2023

World J Clin Cases

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BACKGROUND Various immune-mediated inflammatory diseases consisting of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA), are found to have a substantial societal burden, increased healthcare costs, and progressive disability. Studies suggest that patients with vs without comorbid depression have a more significant disability, a lower likelihood of remission, and reduced adherence to therapy. Elevated interleukin (IL)-1β, tumor necrosis factor-α, and IL-6 contribute to developing depression by the impaired physiological responses to stress, resulting in increased pain, fever, fatigue, and lack thereof of interest, and thus poor long-term outcomes. This study emphasizes the timely recognition of the prevalence of major depressive disorder (MDD) in patients with RA and IBD combined, thus preventing disability. AIM To identify the prevalence level and temporal trends of depression in hospitalized IBD-RA patients. METHODS All adult hospitalized patients from January 2000 to December 2019 in the nationwide inpatient sample (NIS) were captured. The study population included all patients with a primary or secondary IBD-RA overlap disease using corresponding international classification of diseases (ICD)-9 and ICD-10 codes. IBD includes Crohn’s disease and ulcerative colitis. The study population was divided into IBD-RA without MDD (controls) and IBD-RA with MDD (cases). For group comparison between MDD vs no MDD, we used Student's t -test for continuous variables and Rao-Scott Chi-square tests for categorical variables. For univariate analyses, we used logistic regression, and for multivariate analysis, we used a weighted multi-level mixed-effects model. We attested all hypotheses with two-tailed significance level of 0.05 ( P < 0.05 was considered significant). The outcome is to examine the temporal trends and prevalence of depression in patients with IBD-RA by gender, race, and age. RESULTS A total of 133315 records were identified with IBD-RA overlap, of which 26155 patients (19.62%) had MDD. Among the IBD-RA patients, those who had MDD were younger [mean age of 56 years (SD ± 15)] to IBD-RA without MDD patients with a P < 0.0001, more females (80% among cases vs 73% among controls) than males with a P < 0.0001, frequent in the white race (79% among cases vs 73% among controls) than black race. Over the 19 years, the number of patients with MDD in IBD-RA increased from 153 (the year 2000) to 2880 (the year 2019) in weighted NIS, representing a 1782% increase compared to the year 2000 with a P < 0.001. Factors associated with higher MDD included younger age, female gender, white race, alcohol, opioids, esophageal disorders, peptic ulcer disease, chronic pancreatit...

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“…In addition, the increase in the elderly population requires investigating the characteristics of depression, which negatively affects social interaction, causes undernutrition, reduces the quality of life, causes pain, and has a significant economic impact due to high treatment costs. [7] Depression is a major global health problem characterized by symptoms such as altered mood, loss of interest and pleasure, and impairment in cognitive and physical functions. Patients hospitalized for medical conditions have a higher risk of depression than the general population.…”

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confidence: 99%

Risks of undernutrition and depression in hospitalized patients: A cross-sectional study

Asma,

Tuncer

2023

Medicine

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Undernutrition in hospitalized patients is a significant healthcare burden worldwide. Depression is a major global health problem characterized by symptoms such as altered mood, loss of interest and pleasure, and impairment in cognitive and physical functions. Patients hospitalized for medical conditions have a higher risk of depression than the general population. The purpose of this study was to explore the relationship between undernutrition risk and depression risk in hospitalized patients. The design of this study was an observational cross-sectional analytic. A questionnaire form created by the investigator including sociodemographic data, dietary patterns, presence of chronic diseases and anthropometric measurements, Nutritional Risk Screening and Patient Health Questionnaire-2 were applied to the patients. All quantitative data were expressed as the median and interquartile range and qualitative data were expressed as numbers and percentage. Mann–Whitney U test and Kruskal–Wallis test were used to analyze nonparametric data; Chi-square and Fisher Exact test were used to analyze qualitative data. P < .05 was considered statistically significant. A total of 308 patients who met the criteria were reached. Undernutrition was detected in 28.6% of the participants, and depression was present in 37.3%. A statistically significant relationship was found between the risk of undernutrition and the risk of depression, with individuals without a risk of depression being found to have a lower risk of undernutrition. (P < .001). The risk of undernutrition was found to increase with advancing age. Moreover, individuals with higher values for arm muscle area, arm muscle circumference, mid-upper arm circumference, triceps skinfold thickness, calf circumference, and body mass index had a lower risk of undernutrition. No relationship was found between gender and the risk of depression. However, a statistically significant relationship was observed between age and the risk of depression, indicating that older patients had a higher risk of depression. In this study, a statistically significant relationship was found between the risk of undernutrition and the risk of depression in hospitalized patients. It was observed that the risk of undernutrition was lower in individuals without risk of depression.

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The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

Cited by 16 publications

References 315 publications

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis

Risks of undernutrition and depression in hospitalized patients: A cross-sectional study

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