Zinc supplementation and TNF-α levels in vaccinated cardiac patients

Yalçin, Sıddıka Songül; Engür, Defne; Alehan, Dursun; Yurdakök, Kadriye; Özkutlu, Süheyla; Coşkun, Turgay

doi:10.1016/j.jtemb.2011.03.002

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…IL-2 production is improved when zinc level is maintained by giving zinc supplement. In a study by Yalçın et al (2011), zinc supplementation had a beneficial effect on immune response and increased serum TNF-α level after irradiation In this study zinc supplementation before irradiation showed a reduction in serum levels of IL-6. Wellinghausen et al (1997) observed that zinc affects a functional activation or inhibition of isolated immune cells and also appears to influence cell growth and cytokine production and is used for treatment of radiotherapy caused dermatitis (Alterio et al, 2007).…”

mentioning

confidence: 58%

Ameliorating Effects of Bone Marrow Transplantation and Zinc Supplementation on Physiological and Immunological Changes in γ-Irradiated Rats.

Ashry

2017

Egypt. J. Rad.Sci.

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mentioning

confidence: 58%

Ameliorating Effects of Bone Marrow Transplantation and Zinc Supplementation on Physiological and Immunological Changes in γ-Irradiated Rats.

Ashry

2017

Egypt. J. Rad.Sci.

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“…All this leads to a state of immune under-functioning, which has been proved also by a study carried out by Prasad et al that showed that the reduction of IL-2, IL-1β and TNF-α gene expression occurs in conjunction with the decrease in zinc concentration available [9]. This effect is probably due to the ion action on the zinc-dependant transcription factors involved in the genes expression of these cytokines [10,11]. This ion is also responsible for the inactivation of other enzymes (MMPs) which play a role in immune and phlogistic mechanisms.…”

Section: Discussionmentioning

confidence: 83%

The possible role of zinc in the etiopathogenesis of endometriosis

Em¹,

Mt²,

Mainini³

et al. 2014

Clin. Exp. Obstet. Gynecol.

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“…Another study of 9- to 18-year-old heart disease patients found that supplementing with zinc along with the influenza vaccine could reduce the incidence of malaise, a common adverse effect of the influenza vaccine. Besides, this study showed that zinc supplementation along with influenza vaccine could significantly reduce serum levels of TNFα in these children [ 165 ]. However, studies on the elderly have shown that zinc supplementation does not significantly affect the effectiveness of the influenza vaccine.…”

Section: Resultsmentioning

confidence: 99%

Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation

Sadeghsoltani

Mohammadzadeh

Safari

et al. 2021

Biol Trace Elem Res

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Influenza viruses, respiratory syncytial virus (RSV), and SARS-COV2 are among the most dangerous respiratory viruses. Zinc is one of the essential micronutrients and is very important in the immune system. The aim of this narrative review is to review the most interesting findings about the importance of zinc in the anti-viral immune response in the respiratory tract and defense against influenza, RSV, and SARS-COV2 infections. The most interesting findings on the role of zinc in regulating immunity in the respiratory tract and the relationship between zinc and acute respiratory distress syndrome (ARDS) are reviewed, as well. Besides, current findings regarding the relationship between zinc and the effectiveness of respiratory viruses’ vaccines are reviewed. The results of reviewed studies have shown that zinc and some zinc-dependent proteins are involved in anti-viral defense and immune regulation in the respiratory tract. It seems that zinc can reduce the viral titer following influenza infection. Zinc may reduce RSV burden in the lungs. Zinc can be effective in reducing the duration of viral pneumonia symptoms. Zinc may enhance the effectiveness of hydroxychloroquine in reducing mortality rate in COVID-19 patients. Besides, zinc has a positive effect in preventing ARDS and ventilator-induced lung damage. The relationship between zinc levels and the effectiveness of respiratory viruses’ vaccines, especially influenza vaccines, is still unclear, and the findings are somewhat contradictory. In conclusion, zinc has anti-viral properties and is important in defending against respiratory viral infections and regulating the immune response in the respiratory tract.

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Zinc supplementation and TNF-α levels in vaccinated cardiac patients

Cited by 10 publications

References 28 publications

Ameliorating Effects of Bone Marrow Transplantation and Zinc Supplementation on Physiological and Immunological Changes in γ-Irradiated Rats.

Ameliorating Effects of Bone Marrow Transplantation and Zinc Supplementation on Physiological and Immunological Changes in γ-Irradiated Rats.

The possible role of zinc in the etiopathogenesis of endometriosis

Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation

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