Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis

Nazari, Matin; Ashtary‐Larky, Damoon; Nikbaf-Shandiz, Mahlagha; Goudarzi, Kian; Bagheri, Reza; Dolatshahi, Sina; Omran, Hossein Salehi; Amirani, Niusha; Ghanavati, Matin; Asbaghi, Omid

doi:10.1016/j.jtemb.2023.127244

Cited by 5 publications

(3 citation statements)

References 116 publications

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“…The anti-inflammatory and antioxidant properties of zinc may also have broad therapeutic effects in cardiovascular diseases. Zinc supplementation significantly reduced nitric oxide, MDA, TAC, and GSH levels [194] (Table 3). acid, which is associated with the reduction of CoQ10 to ubiquinol, thereby limiting mitochondrial lipid peroxidation caused by GPX4 downregulation [129].…”

Section: Related Adjunctive Therapies or Supplements Increase Antioxi...mentioning

confidence: 91%

“…The anti-inflammatory and antioxidant properties of zinc may also have broad therapeutic effects in cardiovascular diseases. Zinc supplementation significantly reduced nitric oxide, MDA, TAC, and GSH levels [194] (Table 3). * The raw mean difference can be scaled with the inverse variance weight to define the weighted mean difference.…”

Section: Related Adjunctive Therapies or Supplements Increase Antioxi...mentioning

confidence: 92%

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Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

Chen,

Wang,

Chang

et al. 2024

IJMS

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Mitochondria are critical for providing energy to maintain cell viability. Oxidative phosphorylation involves the transfer of electrons from energy substrates to oxygen to produce adenosine triphosphate. Mitochondria also regulate cell proliferation, metastasis, and deterioration. The flow of electrons in the mitochondrial respiratory chain generates reactive oxygen species (ROS), which are harmful to cells at high levels. Oxidative stress caused by ROS accumulation has been associated with an increased risk of cancer, and cardiovascular and liver diseases. Glutathione (GSH) is an abundant cellular antioxidant that is primarily synthesized in the cytoplasm and delivered to the mitochondria. Mitochondrial glutathione (mGSH) metabolizes hydrogen peroxide within the mitochondria. A long-term imbalance in the ratio of mitochondrial ROS to mGSH can cause cell dysfunction, apoptosis, necroptosis, and ferroptosis, which may lead to disease. This study aimed to review the physiological functions, anabolism, variations in organ tissue accumulation, and delivery of GSH to the mitochondria and the relationships between mGSH levels, the GSH/GSH disulfide (GSSG) ratio, programmed cell death, and ferroptosis. We also discuss diseases caused by mGSH deficiency and related therapeutics.

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Section: Related Adjunctive Therapies or Supplements Increase Antioxi...mentioning

confidence: 91%

“…The anti-inflammatory and antioxidant properties of zinc may also have broad therapeutic effects in cardiovascular diseases. Zinc supplementation significantly reduced nitric oxide, MDA, TAC, and GSH levels [194] (Table 3). * The raw mean difference can be scaled with the inverse variance weight to define the weighted mean difference.…”

Section: Related Adjunctive Therapies or Supplements Increase Antioxi...mentioning

confidence: 92%

Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

Chen,

Wang,

Chang

et al. 2024

IJMS

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“…It therefore represents an essential trace element that exerts essential roles in physiological and biochemical processes [ 44 ]. The increased intracellular accumulation of Ca 2+ ions leads to stiffened arteries, and the respective deficiency could reduce vasodilatation at the receptor level [ 45 , 46 , 47 ].…”

Section: Essential Trace Elementsmentioning

confidence: 99%

The Role of Trace Elements in Cardiovascular Diseases

Wechselberger,

Messner,

Bernhard

2023

Toxics

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Essential trace elements play an important role in human physiology and are associated with various functions regulating cellular metabolism. Non-essential trace elements, on the other hand, often have well-documented toxicities that are dangerous for the initiation and development of diseases due to their widespread occurrence in the environment and their accumulation in living organisms. Non-essential trace elements are therefore regarded as serious environmental hazards that are harmful to health even in low concentrations. Many representatives of these elements are present as pollutants in our environment, and many people may be exposed to significant amounts of these substances over the course of their lives. Among the most common non-essential trace elements are heavy metals, which are also associated with acute poisoning in humans. When these elements accumulate in the body over years of chronic exposure, they often cause severe health damage in a variety of tissues and organs. In this review article, the role of selected essential and non-essential trace elements and their role in the development of exemplary pathophysiological processes in the cardiovascular system will be examined in more detail.

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Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology

Angelone,

Rocca,

Lionetti

et al. 2024

Antioxidants & Redox Signaling

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Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis

Cited by 5 publications

References 116 publications

Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

The Role of Trace Elements in Cardiovascular Diseases

Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology

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