Zinc Sulfate in Narrow Range as an In Vitro Anti-HSV-1 Assay

Fani, Mona; Khodadad, Nastaran; Ebrahimi, Saeedeh; Nahidsamiei, Rahil; Makvandi, Manoocher; Teimoori, Ali; Langari, Hadis

doi:10.1007/s12011-019-01728-0

Cited by 9 publications

(8 citation statements)

References 10 publications

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“…Although the effect of zinc ion against a wide range of viral pathogens has been proven since 1967, the utilization of it as a viral medication has been restricted as it is quite toxic for host cells (29).…”

Section: Discussionmentioning

confidence: 99%

“…The extracted RNA was then subjected to reverse transcription using the cDNA Synthesis Kit (Bio fact, Korea). The late gene UL27 (encoding glycoprotein gB) were determined by using Rotor-Gene Q instrument in a thermal pro le of 95 °C for 2 min (1 cycle), 95 °C for 30 s, and 60 °C for 15 s (35 cycles, respectively) (29). The transcription levels of total RNA in each sample were normalized against the GAPDH gene.…”

Section: *Viral Titer Formulamentioning

confidence: 99%

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WITHDRAWN: Inhibitory Effect of ZnO-NPs and NF-CS-ZnO Nano-Hybrid Against Herpes Simplex Virus Type 1 Infection

Abbasi¹,

Arab‐Bafrani²,

Zabihi³

et al. 2021

Preprint

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Background: Since the viruses are intracellular parasite and their replication depends on the host cells, to develop a medication against the viral infections, some substances should be provided having no damage on the host’s cells and tissue. Although the antiviral effects of zinc ion against the viral pathogens has been conspicuous, undesirably it shows a severe toxicity on the cells in cell culture and host tissues in animal models. Methods: To optimize, zinc oxide nanoparticles with antiviral property at the lowest cell toxicity, nano-fibrillar chitosan-ZnO nano-hybrid was synthesized and then, its inhibitory effect against the HSV replication was investigated in comparison to ZnO nanoparticles using plaque reduction and Real time PCR method. Results: Although the infectivity of HSV-1 was reduced in initial steps of virus entry, the significant reduction of viral titer was observed in post exposure of Nano particles on HSV-1 infected cells. In contrary, no changes of viral load were identified in pre-incubation experiment, co-incubation of virus and nanoparticles prior to virus inoculation. Conclusion: Nano-fibrillar CS could dramatically decrease the cell cytotoxicity of ZnO, even though the antiviral effect of ZnO nanoparticles did not change. Nano hybrids appears to penetrate into the host cells and intracellularly inhibits the virus multiplication.

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Section: Discussionmentioning

confidence: 99%

Section: *Viral Titer Formulamentioning

confidence: 99%

WITHDRAWN: Inhibitory Effect of ZnO-NPs and NF-CS-ZnO Nano-Hybrid Against Herpes Simplex Virus Type 1 Infection

Abbasi¹,

Arab‐Bafrani²,

Zabihi³

et al. 2021

Preprint

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show abstract

“…In vitro experiments have shown that zinc impairs viral replication and has beneficial effects on RNA viruses like coronavirus. Zinc supplementation in children documented to be deficient has been shown to decrease mortality, although data are inconsistent 49,50 . No consistent data show zinc supplementation in intensive care patients to be of benefit 51 .…”

Section: Potential Nutrition Interventions Based On Theory Extrapolamentioning

confidence: 99%

Nutrition Therapy in Critically Ill Patients With Coronavirus Disease 2019

Martindale

Patel

Taylor

et al. 2020

J Parenter Enteral Nutr

172

283

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In the midst of a coronavirus disease 2019 (COVID‐19) pandemic, a paucity of data precludes derivation of COVID‐19–specific recommendations for nutrition therapy. Until more data are available, focus must be centered on principles of critical care nutrition modified for the constraints of this disease process, ie, COVID‐19–relevant recommendations. Delivery of nutrition therapy must include strategies to reduce exposure and spread of disease by providing clustered care, adequate protection of healthcare providers, and preservation of personal protective equipment. Enteral nutrition (EN) should be initiated early after admission to the intensive care unit (ICU) using a standard isosmolar polymeric formula, starting at trophic doses and advancing as tolerated, while monitoring for gastrointestinal intolerance, hemodynamic instability, and metabolic derangements. Intragastric EN may be provided safely, even with use of prone‐positioning and extracorporeal membrane oxygenation. Clinicians should have a lower threshold for switching to parenteral nutrition in cases of intolerance, high risk of aspiration, or escalating vasopressor support. Although data extrapolated from experience in acute respiratory distress syndrome warrants use of fiber additives and probiotic organisms, the lack of benefit precludes a recommendation for micronutrient supplementation. Practices that increase exposure or contamination of equipment, such as monitoring gastric residual volumes, indirect calorimetry to calculate requirements, endoscopy or fluoroscopy to achieve enteral access, or transport out of the ICU for additional imaging, should be avoided. At all times, strategies for nutrition therapy need to be assessed on a risk/benefit basis, paying attention to risk for both the patient and the healthcare provider.

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“…Singh et al, in their randomized, double-blind, placebo-controlled trial study, reported the ameliorative effect of zinc in reducing the duration of colds [ 79 ]. Some other studies have indicated the antiviral activity of zinc against various viruses including influenza [ 80 ], rhinovirus, herpes virus, respiratory syncytial virus and transmissible gastroenteritis virus [ 81 ]. Such immunomodulatory and antiviral properties of zinc, highlights its potential role as a supportive agent in the treatment of COVID-19.…”

Section: The Roles Of Zinc In the Inhibition Of Acute Respiratory Distress Syndrome (Ards)mentioning

confidence: 99%

The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection

et al. 2021

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The concern of today's communities is to find a way to prevent or treat COVID-19 and reduce its symptoms in the patients. However, the genetic mutations and more resistant strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge; the designed vaccines and adjuvant therapies would potentially control the symptoms and severity of COVID-19. The most important complication of this viral infection is acute respiratory distress syndrome, which occurs due to the infiltration of leukocytes into the alveoli and the raised cytokine storm. Interferons, as a cytokine family in the host, play an important role in the immune-related antiviral defense and have been considered in the treatment protocols of COVID-19. In addition, it has been indicated that some nutrients, including vitamin D, magnesium and zinc are essential in the modulation of the immune system and interferon (IFN) signaling pathway. Several recent studies have investigated the treatment effect of vitamin D on COVID-19 and reported the association between optimal levels of this vitamin and reduced disease risk. In the present study, the synergistic action of vitamin D, magnesium and zinc in IFN signaling is discussed as a treatment option for COVID-19 involvement.

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Zinc Sulfate in Narrow Range as an In Vitro Anti-HSV-1 Assay

Cited by 9 publications

References 10 publications

WITHDRAWN: Inhibitory Effect of ZnO-NPs and NF-CS-ZnO Nano-Hybrid Against Herpes Simplex Virus Type 1 Infection

WITHDRAWN: Inhibitory Effect of ZnO-NPs and NF-CS-ZnO Nano-Hybrid Against Herpes Simplex Virus Type 1 Infection

Nutrition Therapy in Critically Ill Patients With Coronavirus Disease 2019

The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection

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