Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

Abstract

A number of studies have reported that zinc plays a substantial role in the development of metabolic syndrome, taking part in the regulation of cytokine expression, suppressing inflammation, and is also required to activate antioxidant enzymes that scavenge reactive oxygen species, reducing oxidative stress. Zinc also plays a role in the correct functioning of lipid and glucose metabolism, regulating and forming the expression of insulin. In numerous studies, zinc supplementation has been found to improve blood pressure, glucose, and LDL cholesterol serum level. Deeper knowledge of zinc’s properties may help in treating metabolic syndrome, thus protecting against stroke and angina pectoris, and ultimately against death.

Effect of Zinc Source and Exogenous Enzymes Supplementation on Zinc Status in Dogs Fed High Phytate Diets

“…Zinc can have an anti-inflammatory role by lowering the secretion of CRP, which is an acute-phase protein secreted in response to an increase in pro-inflammatory cytokines, namely of interleukin 6 [50]. Even though Zn supplementation is more efficient decreasing the CRP of ill patients, basal levels of CRP can also benefit from Zn supplementation [51].…”

Association of whole blood copper, magnesium and zinc levels with metabolic syndrome components in 6–12-year-old rural Chinese children: 2010–2012 China National Nutrition and Health Survey

“…Copper (Cu), magnesium (Mg) and zinc (Zn) are all important trace elements involved in various metabolic pathways [4,5]. Copper and Zn play an important role in oxidative stress and in ammation [6,7], as co-factors of antioxidant enzymes [8]. Magnesium is the second most abundant intracellular ion after potassium, and Mg de ciency is associated with several diseases, such as coronary heart disease and type 2 diabetes [9].…”

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

“…During chronic deficiency, the production of pro-inflammatory cytokines increases, influencing the outcome of a large number of inflammatory, metabolic, neurodegenerative and immune diseases (11). diseases such as rheumatoid arthritis, diabetes (12), atherosclerosis and obesity (13), impaired cognitive function (14), as well as age-related macular degeneration (AMd) may be due to zinc deficiency, worsening chronic inflammation and triggering oxidative stress. coronaviridae were considered as the etiological agent in 6-29% of respiratory infections (15,16), although the severity of the disease varies significantly on the particular virus and its virulence (17).…”

“…due to the clearly demonstrated role of zinc in immunity (2), and impaired zinc status in ageing (35), metabolic diseases including diabetes, obesity, and cardiovascular diseases (13), it is speculated that zinc compounds may be used as an adjunct therapy in cOVId-19 treatment (36) for increasing antiviral resistance (37). Of note, zinc was earlier suggested as the potential agent for immune support and prevention of H1N1 influenza ('swine flu') (38).…”