Zinc selective chemosensor based on pyridyl-amide fluorescence

Lee, Hong Gyu; Lee, Ju-Hoon; Jang, Seung Pyo; Park, Hyun Min; Kim, Sung Jin; Kim, Youngmee; Kim, Cheal; Harrison, Roger G.

doi:10.1016/j.tet.2011.08.049

Cited by 70 publications

(25 citation statements)

References 30 publications

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“…Detection limit for Zn 2+ , based on 3σ/slope, was analyzed to be 1.08 μM from the calibration (Figure ) . It is far below the WHO standard (76.0 μM) …”

Section: Resultsmentioning

confidence: 99%

“…When acceptor chelates to metal ions, fluorophore translates the binding into fluorescent signal . Several moieties have been frequently adopted for these systems, for examples, rhodamine dyes, amides, naphthalimides, pyrenes, azamacrocycles, and Schiff bases . Among the moieties, Schiff bases can be synthesized simply and perform as binding site .…”

Section: Introductionmentioning

confidence: 99%

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Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells

Jang

Kim

Jung

et al. 2018

Bulletin Korean Chem Soc

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A fluorescence chemosensor HBC ((E)‐3‐((2‐hydroxybenzylidene)amino)benzofuran‐2‐carboxamide) for detection of Zn2+ was designed by the condensation combination of 3‐aminobenzofuran‐2‐carboxamide and salicylaldehyde. Sensor HBC showed an excellent selective “off–on” fluorescent response toward Zn2+. Detection limit (1.08 μM) for Zn2+ was much lower than the WHO standard (76.0 μM). Importantly, HBC could recognize and quantify Zn2+ in real samples and live cells. Detection process of HBC for Zn2+ was explained by ESI‐mass, Job plot, UV–Vis and 1H NMR titrations, and theoretical calculations.

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“…Detection limit for Zn 2+ , based on 3σ/slope, was analyzed to be 1.08 μM from the calibration (Figure ) . It is far below the WHO standard (76.0 μM) …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells

Jang

Kim

Jung

et al. 2018

Bulletin Korean Chem Soc

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“…The action of DPA with Cu 2+ led to the photo-induced electron transfer (PET) process from the fluorophore to the Cu 2+ , showing the fluorescence quenching. 36,37 The oxygen atoms on the P-O in PPi have strong coordination with Cu 2+ . 28 The addition of PPi to the above system would compete with the PPE-DPA system in the binding of Cu 2+ , and then result in a partial recovery in the fluorescence intensity of PPE-DPA-Cu 2+ by blocking the PET pathway.…”

Section: Spectral Properties Of Ppe-dpamentioning

confidence: 99%

A Conjugated Polymer Fluorescent Sensor for Continuous Identification of Copper(II) and Pyrophosphate in Blood Serum and Synovial Fluid

Guan

et al. 2019

ANAL. SCI.

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A novel "on-off-on" super-sensitive conjugated polymer fluorescence sensor (PPE-DPA) was developed and it was applied to realize the continuous recognition of Cu 2+ and pyrophosphate (PPi). The fluorescence intensity decreased linearly with the change of Cu 2+ from 0.05 to 5.0 μmol L -1 and the limit of detection was 24 nmol L -1 . The fluorescence intensity was linearly enhanced with the increase of PPi from 0.5 to 12.0 μmol L -1 and the limit of detection was 230 nmol L -1 . In addition, this method was applied to detect PPi in the blood serum and synovial fluid of patients with arthritis and satisfactory results were obtained. Thus, the PPE-DPA is not only an effective tool for detecting Cu 2+ and PPi in samples, but also presents a potential way to diagnose arthritis.

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“…The binding of ZnA-DPA to zinc could not be assessed due to the lack of a chromophore. Dissociation constants for compounds analogous to ZnA-DPA and ZnA-Pyr were in the low nanomolar [93] and high femtomolar [94] ranges, respectively. PAC-1 , TPEN , ZnA-DPA , and ZnA-Pyr were evaluated in PC-12 cells in a 24-hour experiment.…”

Section: Pac-1 Derivative Librariesmentioning

confidence: 99%

Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities

Roth¹,

Hergenrother

2016

CMC

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PAC-1 induces the activation of procaspase-3 in vitro and in cell culture by chelation of inhibitory labile zinc ions via its ortho-hydroxy-N-acylhydrazone moiety. First reported in 2006, PAC-1 has shown promise in cell culture and animal models of cancer, and a Phase I clinical trial in cancer patients began in March 2015 (NCT02355535). Because of the considerable interest in this compound and a well-defined structure-activity relationship, over 1000 PAC-1 derivatives have been synthesized in an effort to vary pharmacological properties such as potency and pharmacokinetics. This article provides a comprehensive examination of all PAC-1 derivatives reported to date. A survey of PAC-1 derivative libraries is provided, with an in-depth discussion of four derivatives on which extensive studies have been performed.

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Zinc selective chemosensor based on pyridyl-amide fluorescence

Cited by 70 publications

References 30 publications

Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells

Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells

A Conjugated Polymer Fluorescent Sensor for Continuous Identification of Copper(II) and Pyrophosphate in Blood Serum and Synovial Fluid

Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities

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