Zinc Oxide Nanorod‐Based Piezoelectric Dermal Patch for Wound Healing

Abstract

Current treatments for wound healing engage in passive healing processes and rarely participate in stimulating skin cell behaviors for active wound healing. Electric potential difference-derived electrical fields (EFs) are known to modulate skin cell behaviors. Here, a piezoelectric dermal patch is developed that can be applied on skin wound site and EF is generated to promote wound healing. The one-directionally aligned zinc oxide nanorodbased piezoelectric patch generates piezoelectric potential upon mechanical deformations induced by animal motion, and induces EF at the wound bed. In vitro and in vivo data demonstrate that the piezoelectric patch promotes the wound healing process through enhanced cellular metabolism, migration, and protein synthesis. This modality may lead to a clinically relevant piezoelectric dermal patch therapy for active wound healing.

Rapid Sterilization and Accelerated Wound Healing Using Zn2+ and Graphene Oxide Modified g‐C3N4 under Dual Light Irradiation

“…As for the mechanism of Zn 2+ enhancing the expression of the above‐mentioned genes, previous studies demonstrated that transforming growth factor‐β (TGF‐β), a multi‐functional cytokine involved in cellular proliferation, differentiation, migration, extracellular matrix production, and remodeling, which could stimulate the movement of fibroblasts from the adjacent intact to wound site . Owing to the enhanced TGF‐β signaling, both collagen (specially COL I and COL III) and MMP‐2 genes are upregulated for tissue organization and basement membrane regeneration during wound healing . In addition, Zn 2+ can participate in the chemosynthesis of zinc‐based metalloenzymes such as alkaline phosphatase, RNA, DNA polymerases, and MMPs .…”

Thermosensitive, Stretchable, and Piezoelectric Substrate for Generation of Myogenic Cell Sheet Fragments from Human Mesenchymal Stem Cells for Skeletal Muscle Regeneration

“…Quantitative real‐time polymerase chain reaction (qPCR) analysis of caspase‐3 indicated that MS of 3% and PP of 120 mV did not induce apoptosis of hUCBMSCs, in accordance to previous studies. Our previous study has shown that PP up to 900 mV does not affect cell viability as determined with MTT (Thiazolyl Blue Tetrazolium Bromide) and Neutral Red assay . Meanwhile, a study reported that MS at an amplitude up to 12% does not reduce cell viability as determined with calcein AM and EthD‐1 uptake assay …”

Chitosan-Graphene Oxide-Based Ultra-Thin and Flexible Sensor for Diabetic Wound Monitoring

“…Flexible and biocompatible functional materials such as Pu/PVDF scaffold and ZnO nanorods composite etc. [5,6] have been used in active wound dressing to accelerate the healing process through electrical stimulation of wound. Recently, biodegradable piezoelectric glycine has also been proposed for the fabrication of a flexible self-powered stress sensor for continuous monitoring of applied stress around the wound site under compression bandages [7].…”