Zinc oxide 3Dmicrostructures as an antimicrobial filler content for composite resins

Abstract

The aim of this study was to evaluate the antibacterial activity of a composite resin modified by 3D zinc oxide (ZnO) microstructures and to verify possible alterations on its mechanical properties. ZnO was synthesized by hydrothermal approach and characterized by X-ray diffraction (XRD), surface area by Brunauer, Emmett and Teller (BET), Fourier transform infrared spectroscopy (FTIR) and Field emission scanning electron microscopy (FESEM). The minimum inhibitory concentrations of ZnO against Streptococcus mutans, Escherichia coli, Staphylococcus aureus, and Candida albicans were determinated. The composite resin Filtek Z350XT (3M of Brazil) was blended with 0.2%, 0.5%, and 1% in weight of ZnO and submitted to antibacterial assay by direct contact test against S. mutans, the leading cause of dental caries and the most cariogenic oral streptococci. Additionally, it was performed compressive and diametral tensile strength tests of the modified composite resin. Microrods and hollow microrods of ZnO were obtained and its MIC values were found to be 125 μg/mL for S. mutans, 500 μg/mL for C. albicans and 62.5 μg/mL for S. aureus. For the tested concentrations, it was not found MIC against E. coli. The direct contact test showed a significant antibacterial capacity of modified composite resin (p > 0.05 for all concentrations). The compressive and diametral tensile strength remains no changed after inclusion of microparticles (p > 0.05 for all concentrations). The modification of the composite resin with small amounts of ZnO microparticles significantly inhibited the S. mutans growth on resin surface without significant alterations of its mechanical strength.

Properties of Experimental Dental Composites Containing Antibacterial Silver-Releasing Filler

“…The antibacterial filler introduction had no statistically significant effect on DTS, although the mean value for the control group was the lowest. Those findings are in opposition to the results obtained by Łukomska-Szymańska et al [ 101 ], Diaz et al [ 102 ], and Sokołowski et al [ 103 ], where nonfunctionalized calcium fluoride microparticles, zinc oxide three-dimensional microstructures, nanosilver, and nanogold decreased the DTS values of modified composites.…”

A Study of 3D-Printable Reinforced Composite Resin: PMMA Modified with Silver Nanoparticles Loaded Cellulose Nanocrystal

“…Numerous studies have been conducted to improve antibacterial properties for dental restoration materials, such as fluorides [15,30,31], zinc ions [32,33,34,35], silver nanoparticles and silver ions [18,20,25,26,36], and quaternary ammonium groups [25,26,37] are introduced into the fillers through different reaction mechanisms to enhance antimicrobial functions of composite resins. In this study, as the silver content in the resin matrix increased, the antibacterial effect of the resin became more and more significant.…”

Model resin composites incorporating ZnO-NP: activity against S. mutans and physicochemical properties characterization

“…Recent studies have shown that resin composites incorporating ZnO presented antibacterial activity against S. mutans and S. sobrinus 9 , 31 . However, these works have used commercially available resin composites to test this possibility.…”