Zinc-methionine acts as an anti-diarrheal agent by protecting the intestinal epithelial barrier in postnatal Holstein dairy calves

Ma, Fengtao; Wo, Yeqianli; Shan, Qiang; Wei, Jingya; Zhao, Shengguo; Sun, Peng

doi:10.1016/j.anifeedsci.2020.114686

Cited by 7 publications

(8 citation statements)

References 37 publications

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“…Diarrhea is one of the important reasons affecting the growth and production performance of goats and sheep during intensive and grazing farming ( Wang M. et al, 2021 ). A large number of studies have shown that the impaired intestinal epithelial barrier ( Ma et al, 2020 ), low functional immunity of the gastrointestinal tract ( Peng et al, 2021 ), and intestinal flora disturbance can cause diarrhea of different degrees ( Zhang et al, 2021 ). Diarrhea affects the body’s absorption of small molecular substances and nutritional elements ( Esterházy et al, 2019 ), destroys intestinal homeostasis, and results in severe loss of body fluids ( McLamb et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Clostridium butyricum improves the intestinal health of goats by regulating the intestinal microbial community

Zhang

Hou

et al. 2022

Front. Microbiol.

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Clostridium butyricum, as a probiotic with a variety of active products, has been widely used to improve the intestinal health of humans and animals. Previous studies had demonstrated that Clostridium butyricum exhibited potential protective and positive effects in human disease research and animal production by producing a variety of beneficial substances, such as intestinal inflammation, the intestinal epithelial barrier, metabolic diseases, and regulation of the gut microbiota. Therefore, we hypothesized that dietary Clostridium butyricum supplementation could improve gut health in fattening goats by modulating gut microbiota. However, it is unclear whether Clostridium butyricum can reach the intestine through the rumen, so 15 healthy Albas goats were selected and randomly divided into 3 treatments with 5 replicates in each group. The groups were divided as follows: control group (CON: basal diet), rumen-protected Clostridium butyricum group (RPCB: basal diet plus 1.0 × 109 CFU/kg Clostridium butyricum coated with hydrogenated fat), and Clostridium butyricum group (CB: basal diet plus 1.0 × 109 CFU/kg Clostridium butyricum). The experiment was slaughtered after a 70-day growth test, and the jejunal mucosa and intestinal contents of the goats were collected to determine tight junction proteins related genes expression and 16S rDNA microbial sequencing analysis to evaluate the intestine health. The results showed that dietary supplementation with Clostridium butyricum significantly increased the expression of the Claudin-4 gene of the jejunal mucosa (P < 0.05) and had a trend toward a significant increase in the Occludin gene (0.05 < P < 0.10). However, Clostridium butyricum had no significant effect on the expression of intestinal inflammatory factors (P > 0.10). In addition, the relative fractionation of Clostridium and Clostridiaceae_unclassified in the gut microbiota at the genus level decreased significantly compared with controls (P < 0.05). The results of the analysis of the level of Clostridium species showed that Clostridium butyricum only existed in the treatment group. And the correlation results showed that Occludin and Claudin-4 genes were positively correlated with Sharppea and Clostridium butyricum, and negatively correlated with Clostridium (P < 0.05). Supplementing Clostridium butyricum in the diet did not significantly affect the intestinal immune function of goats, while regulation of the intestinal microbiota was associated with improving the intestinal epithelial barrier.

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Section: Introductionmentioning

confidence: 99%

Clostridium butyricum improves the intestinal health of goats by regulating the intestinal microbial community

Zhang

Hou

et al. 2022

Front. Microbiol.

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“…Our research team is dedicated to identifying the optimal low doses of different sources of zinc to alleviate diarrhea and promote growth in dairy calves during their early life. In our previous studies, we found that supplementation with 80 mg zinc/day in the form of ZM or zinc oxide, effectively reduced diarrhea and promoted the growth of dairy calves in the first 2 weeks after birth (12,15). Here in Experiment 1, supplementation with ZP to yield 80 and 120 mg zinc/day significantly reduced the incidence of diarrhea but increased growth performance by increasing ADG and final body weight and decreasing feed-togain ratio during days 1-14.…”

Section: Discussionmentioning

confidence: 70%

“…Accumulated studies have shown that supplementation with zinc enhances the growth performance and immunity of calves (9)(10)(11)(12). Furthermore, organic zinc is generally considered to be more bioavailable than inorganic forms, owning to its enhanced ability to promote the expression of tight junction proteins and zinc transporters in the intestine (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Supplementation With Zinc Proteinate Increases the Growth Performance by Reducing the Incidence of Diarrhea and Improving the Immune Function of Dairy Calves During the First Month of Life

Jin

Gao

et al. 2022

Front. Vet. Sci.

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Two experiments were conducted to identify the optimal dose of zinc proteinate (ZP) in the diet for dairy calves and then to compare early supplementation with the ZP or zinc methionine (ZM) on the growth performance, incidence of diarrhea, antioxidant status, and immune function of dairy calves during their first month of life. In Experiment 1, forty newborn female Holstein dairy calves were randomly divided into four groups (n = 10): a control group (without ZP supplementation, ZP0) or groups that received ZP supplementation at 40, 80, and 120 mg zinc/day, respectively (ZP40, ZP80, and ZP120). The experiment lasted 14 days, and the growth performance, incidence of diarrhea, and serum zinc concentration were analyzed. In Experiment 2, thirty-six newborn female Holstein dairy calves were randomly allocated to three groups (n = 12): a negative control group (without zinc supplementation, CON), a positive control group (supplemented with 80 mg zinc/day in the form of zinc methionine, ZM), and a ZP group (supplemented with 80 mg zinc/day in the form of ZP). The experiment lasted 28 days, and the growth performance, incidence of diarrhea, serum zinc concentration, serum antioxidant indicators, and concentrations of plasma immunoglobulins and cytokines were determined on days 7, 14, 21, and 28. Results showed that in Experiment 1, supplementation with ZP to yield 80 mg zinc/day increased the ADG (P < 0.01) and serum zinc concentration (P < 0.01), and decreased the F/G (P < 0.01) and the incidence of diarrhea (P < 0.05) during days 1–14. In Experiment 2, compared with the CON group, ZP increased the ADG (P < 0.01), serum zinc concentration (P < 0.01), and plasma immunoglobulin G (IgG; P < 0.01) and IgM (P < 0.01) concentrations, but reduced the incidence of diarrhea (P < 0.01), serum malondialdehyde (P < 0.01), and plasma interleukin-1β (P < 0.01) concentrations during days 1–28. Overall, ZP supplementation to yield 80 mg zinc/day improves the growth performance and immune function, and decrease the incidence of diarrhea of dairy calves, which was comparable to the same dose of zinc in the form of ZM.

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“…According to previous studies, starter feed intake did not differ between calves fed organic or inorganic minerals by Osorio et al 5 , Gelsinger et al 40 , Ma et al 41 , and Chang et al 42 ; however, Abdollahi et al 43 reported that calves fed organic zinc had greater feed intake than calves fed inorganic zinc. The positive effect on DMI due to OM supplementation may be related to the higher digestibility reported in calves 43 and dairy cows 44 fed OM compared to IM.…”

Section: Discussionmentioning

confidence: 87%

“…For example, Brugger and Windisch 53 reported that Zn positively affects the modulation of inflammatory responses and the development of the gut microbiota, and inflammation and infection increased in zinc-deficient animals 54 . More recently, Ma et al 41 reported that Zn-Met supplementation improves intestinal mucosal barrier integrity.…”

Section: Discussionmentioning

confidence: 99%

Trace minerals source in calf starters interacts with birth weights to affect growth performance

Mousavi-Haghshenas

Hashemzadeh

Ghorbani

et al. 2022

Sci Rep

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The present study was conducted to investigate the effects of partial replacement of inorganic minerals (IM) with trace minerals in advance chelate components form in starter diets for calves of different birth weights on performance, health, and behavior of Holstein calves. Fifty-two calves were assigned to 1 of 4 treatments in a 2 × 2 factorial arrangement with two mineral sources (IM or advanced chelated minerals (ACMS)) and two birth weights (low or normal birth weight; LBW or NBW). Calves were weaned on d 56 and remained until d 71 of the study. Results showed that NBW calves had higher feed intake, withers and hip height, larger heart girth and lower fecal score than LBW calves throughout the study. Calves receiving ACMS tended to have higher feed intake, larger hip width, lower eye and nose scores, and lower rectal temperature throughout the study than IM calves. In addition, ACMS calves had larger abdominal girths at d 56 of the study compared to IM calves. Interactions between birth weights and mineral sources for preweaning average daily gain (ADG) and weaning and final BW showed that ACMS supplementation improved ADG and BW in LBW calves. Non-nutritive oral behavior was lower in ACMS calves compared to IM calves during all periods. Overall, ACMS feeding decreased non-nutritive oral behavior and improved calf health status during the study. In addition, feeding ACMS to dairy calves with LBW increased their ADG to a similar extent as to NBW calves, suggesting an improvement in their efficiency.

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Zinc-methionine acts as an anti-diarrheal agent by protecting the intestinal epithelial barrier in postnatal Holstein dairy calves

Cited by 7 publications

References 37 publications

Clostridium butyricum improves the intestinal health of goats by regulating the intestinal microbial community

Clostridium butyricum improves the intestinal health of goats by regulating the intestinal microbial community

Supplementation With Zinc Proteinate Increases the Growth Performance by Reducing the Incidence of Diarrhea and Improving the Immune Function of Dairy Calves During the First Month of Life

Trace minerals source in calf starters interacts with birth weights to affect growth performance

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