Zinc is involved in regulation of secretion from intestinal epithelium in weaned piglets

Carlson, D.; Sehested, Jakob; Feng, Z.; Poulsen, H

doi:10.1016/j.livsci.2007.01.026

Cited by 4 publications

(3 citation statements)

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“…Zn is an important micronutrient for the overall health and development of infants and young children. It has multiple effects on pathophysiological processes, including the absorptive and secretory processes [ 34 , 35 ], the gut associated immune process [ 36 ], and the metabolic activity of the intestinal microbiota [ 37 , 38 ]. Besides, numerous animal and human studies demonstrated the benefits of Zn supplementation on inflammation and infectious diseases [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets

Long

Chen

Zhang³

et al. 2017

PLoS ONE

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The aim of this study was to compare the effect of dietary supplementation with low dose of porous and nano zinc oxide (ZnO) on weaning piglets, and to evaluate the possibility of using them as an alternative to high dose of regular ZnO. Piglets were randomly allocated into four treatment groups fed with four diets: (1) basal diet (NC), (2) NC+ 3000 mg/kg ZnO (PC), (3) NC + 500 mg/kg porous ZnO (HiZ) and (4) NC + 500 mg/kg nano ZnO (ZNP). The result showed that piglets in HiZ group had less diarrhea than ZNP group (P < 0.05). Besides, there was no significant difference between PC, HiZ and ZNP groups in terms of serum malondialdeyhde (MDA) concentration and glutathione peroxidase (GSH-Px) activity (P > 0.05). Analysis of trace metal elements revealed that piglets fed with high dose of regular ZnO had the highest Zn level in kidney (P < 0.05), which may induce kidney stone formation. Additionally, a decrease in ileal crypt depth was observed in PC, HiZ and ZNP group, suggesting an effective protection against intestinal injury. Results of mRNA analysis in intestine showed that ZNP supplementation had better effects on up-regulated trefoil factor 3 (TFF3) and nuclear factor erythroid 2-related factor 2 (Nrf2) levels in duodenum and jejunum than HiZ did (P < 0.05), implying that nano ZnO may possess higher anti-inflammatory capacity than porous ZnO. In conclusion, dietary supplementation with low dose of porous and nano ZnO had similar (even better) effect on improving growth performance and intestinal morphology, reducing diarrhea and intestinal inflammatory as high dose of regular ZnO in weaning piglets. Compared with nano ZnO, porous ZnO had better performance on reducing diarrhea but less effect on up-regulation of intestinal TFF3 and Nrf2.

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Section: Discussionmentioning

confidence: 99%

Comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets

Long

Chen

Zhang³

et al. 2017

PLoS ONE

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“…Proposed mechanims also include an increase in barrier functions/properties of the intestinal epithelium (Rodriguez et al,. 1996;Carlson et al, 2006;Feng et al, 2006;Hedemann et al, 2006;Hu et al, 2013;Martin et al, 2013;Sanz Fernandez et al, 2013), immunomodulation (Roselli et al, 2005;Kim et al, 2012;Hu et al, 2013) and reduced activation of cAMP-operated K + and Cl − channels leading to reduced loss of water and other osmolytes (Carlson et al, 2007).…”

Section: Therapeutic Use Of Zinc In Pigletsmentioning

confidence: 99%

Scientific Opinion on the potential reduction of the currently authorised maximum zinc content in complete feed

Högstrand¹

2014

EFS2

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A critical review of (i) the zinc requirements of food-producing and pet animals, (ii) the zinc concentration of feed materials and (iii) the calculated background zinc concentration of complete feed supports the possibility of a considerable reduction of the currently authorised maximum concentration for total zinc in feed. The FEEDAP Panel developed, based on an approximation using zinc requirements and background data, potential new maximum contents, which could replace the current ones. The newly proposed total maximum contents are: 150 mg Zn/kg complete feed for piglets, sows, rabbits, salmonids, cats and dogs; 120 mg Zn/kg complete feed for turkeys for fattening; 100 mg Zn/kg complete feed for all other species and categories. The use of phytase in feeding piglets, pigs for fattening and sows would allow a further reduction of the newly proposed total maximum contents by 30 % (from 150 to 110 mg Zn/kg feed for piglets and sows and from 100 to 70 mg Zn/kg feed for pigs for fattening). The newly proposed total maximum contents ensure health, welfare and productivity of the target species and do not affect consumer safety. The FEEDAP Panel expects that the introduction of the newly proposed total maximum contents, provided they are applied in feeding practices, would result in an overall reduction of zinc emissions from animal production of about 20 %. Zinc in Feed, including Noël A. Dierick, Jürgen Gropp, Catherine Jondreville, Marta Lopez Alonso, Anne Katrine Lundebye, Wolfgang Maret and Patrick Schlegel for the preparatory work on this scientific opinion. The Panel also wishes to thank the Authorities of EU Member States and EEA/EFTA countries, and stakeholders who provided information following a call for data on zinc in animal nutrition launched by EFSA. 4 An editorial amendment was carried out on section 6.3 that does not materially affect the contents nor outcome of this Scientific Opinion. To avoid confusion, the original version has been removed from the EFSA Journal, but is available on request, as is a version showing all the changes made. SUMMARYFollowing a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the potential reduction of the currently authorised maximum zinc content in complete feed (250 mg Zn/kg for pet animals, 200 mg Zn/kg for fish and milk replacer and 150 mg Zn/kg for other animal species).To improve the available information on the use of zinc in animal nutrition, EFSA launched a call for data to EU Member States and EEA/EFTA countries and to stakeholders. The data submitted were used in the current Scientific Opinion.Zinc in the form of its divalent metal ion, Zn 2+ , is nutritionally essential for all living organisms. The total amount of zinc in the human body is 2−3 g and its concentrations in tissues are about the same in all mammals. Virtually all its functions are in proteins, in which it is a catalytic, structural, or regulatory cofactor.A critical revi...

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“…Zinc has been shown to have a positive impact on daily gain in the post-weaning period of piglets when administered at so-called pharmacological concentrations [5] . Zinc has multiple effects on physiological and pathophysiological processes, including the diversity and metabolic activity of the intestinal microbiota [6] – [10] , the gut associated immune system [11] and absorptive and secretory processes [1] , [12] , [13] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Zinc Oxide on Morphological Characteristics, Mucin Composition and Gene Expression in the Colon of Weaned Piglets

et al. 2014

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The trace element zinc is often used in the diet of weaned piglets, as high doses have resulted in positive effects on intestinal health. However, the majority of previous studies evaluated zinc supplementations for a short period only and focused on the small intestine. The hypothesis of the present study was that low, medium and high levels of dietary zinc (57, 164 and 2,425 mg Zn/kg from zinc oxide) would affect colonic morphology and innate host defense mechanisms across 4 weeks post-weaning. Histological examinations were conducted regarding the colonic morphology and neutral, acidic, sialylated and sulphated mucins. The mRNA expression levels of mucin (MUC) 1, 2, 13, 20, toll-like receptor (TLR) 2, 4, interleukin (IL)-1β, 8, 10, interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were also measured. The colonic crypt area increased in an age-depending manner, and the greatest area was found with medium concentration of dietary zinc. With the high concentration of dietary zinc, the number of goblet cells containing mixed neutral-acidic mucins and total mucins increased. Sialomucin containing goblet cells increased age-dependently. The expression of MUC2 increased with age and reached the highest level at 47 days of age. The expression levels of TLR2 and 4 decreased with age. The mRNA expression of TLR4 and the pro-inflammatory cytokine IL-8 were down-regulated with high dietary zinc treatment, while piglets fed with medium dietary zinc had the highest expression. It is concluded that dietary zinc level had a clear impact on colonic morphology, mucin profiles and immunological traits in piglets after weaning. Those changes might support local defense mechanisms and affect colonic physiology and contribute to the reported reduction of post-weaning diarrhea.

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Zinc is involved in regulation of secretion from intestinal epithelium in weaned piglets

Cited by 4 publications

References 8 publications

Comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets

Comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets

Scientific Opinion on the potential reduction of the currently authorised maximum zinc content in complete feed

Effect of Dietary Zinc Oxide on Morphological Characteristics, Mucin Composition and Gene Expression in the Colon of Weaned Piglets

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