Zinc ion driven ionic conduction through single asymmetric nanochannels functionalized with nanocomposites

Khalid, Waqas; Abbasi, Muhammad Ali; Ali, Mubarak; Ali, Zulqurnain; Trautmann, C.; Ensinger, Wolfgang

doi:10.1016/j.electacta.2020.135810

Cited by 22 publications

(14 citation statements)

References 53 publications

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“…A macroscopic concept of the rectification is composed of (i) geometric obstacle of the ion transport through the hole in the closed state and (ii) the localized accumulation of electrolyte owing to ion-exchange membrane in the open state [19,29,30]. A concept from the microscopic viewpoints is a gate linked to the potential distribution in the double-layer or on pore walls [31][32][33][34][35][36][37] as well as molecular instability in a hydrodynamic vortex [38,39].…”

Section: Introductionmentioning

confidence: 99%

Electric Migration of Hydrogen Ion in Pore-Voltammetry Suppressed by Nafion Film

Liu

Aoki²,

Chen

2020

Electrochem

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Micro-hole voltammetry exhibiting rectified current-voltage curves was performed in hydrochloric acid by varying the lengths and the diameters of the micro-holes on one end of which a Nafion film was mounted. Some voltammetric properties were compared with those in NaCl solution. The voltammograms were composed of two line-segments, the slope of one segment being larger than the other. They were controlled by electric migration partly because of the linearity of the voltammograms and partly the independence of the scan rates. Since the low conductance which appeared in the current from the hole to the Nafion film was proportional to the cross section area of the hole and the inverse of the length of the hole, it should be controlled by the geometry of the hole. The conductance of the hydrogen ion in the Nafion film was observed to be smaller than that in the bulk, because the transport rate of hydrogen ion by the Grotthuss mechanism was hindered by the destruction of hydrogen bonds in the film. In contrast, the conductance for the current from the Nafion to the hole, enhancing by up to 30 times in magnitude from the opposite current, was controlled by the cell geometry rather than the hole geometry except for very small holes. A reason for the enhancement is a supply of hydrogen ions from the Nafion to increase the concentration in the hole. The concentration of the hydrogen ion was five times smaller than that of sodium ion because of the blocking of transport of the hydrogen ion in the Nafion film. However, the rectification ratio of H+ was twice as large as that of Na+.

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Section: Introductionmentioning

confidence: 99%

Electric Migration of Hydrogen Ion in Pore-Voltammetry Suppressed by Nafion Film

Liu

Aoki²,

Chen

2020

Electrochem

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“…Second, taking advantage of the defined 3D structure of proteins, the assembly and immobilization of receptors can be achieved in a directed and controlled fashion. In contrast, conventional immobilization methods based on non‐covalent electrostatic interactions [ 10 ] or reactions between surface accessible lysine residues with activated N ‐hydroxysuccinimide esters [ 11 ] only provide little control how a fusion protein is immobilized. In particular, immobilization may turn out heterogenous with detrimental effects on the performance of a biosensor especially when the binding site of receptor is occluded.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3,4 ] Key considerations that determine the responsiveness of receptor‐modified nanopores toward a desired analyte concerns their material, size, geometry, and surface properties. [ 3 ] In this regard, several label‐free sensors have been developed exploiting small molecules [ 5–7 ] or DNA aptamers [ 8,9 ] as receptors to detect a range of different analytes including metal ions, [ 5,10 ] low molecular weight ligands, [ 6,8,11 ] nucleic acids, [ 12 ] or proteins. [ 7,9,13,14 ] In contrast, the use of receptor proteins has been limited to a few model interactions, in particular, conventional antibody‐antigen combinations and streptavidin‐biotin.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive and Selective Protein Recognition with Nanobody‐Functionalized Synthetic Nanopores

Duznovic

Gräwe

Weber

et al. 2021

Small

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The development of flexible and reconfigurable sensors that can be readily tailored toward different molecular analytes constitutes a key goal and formidable challenge in biosensing. In this regard, synthetic nanopores have emerged as potent physical transducers to convert molecular interactions into electrical signals. Yet, systematic strategies to functionalize their surfaces with receptor proteins for the selective detection of molecular analytes remain scarce. Addressing these limitations, a general strategy is presented to immobilize nanobodies in a directional fashion onto the surface of track‐etched nanopores exploiting copper‐free click reactions and site‐specific protein conjugation systems. The functional immobilization of three different nanobodies is demonstrated in ligand binding experiments with green fluorescent protein, mCherry, and α‐amylase (α‐Amy) serving as molecular analytes. Ligand binding is resolved using a combination of optical and electrical recordings displaying quantitative dose–response curves. Furthermore, a change in surface charge density is identified as the predominant molecular factor that underlies quantitative dose–responses for the three different protein analytes in nanoconfined geometries. The devised strategy should pave the way for the systematic functionalization of nanopore surfaces with biological receptors and their ability to detect a variety of analytes for diagnostic purposes.

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“…Reproduced with permission. [273] Copyright 2020, Elsevier. modification, for the enantioselective recognition of SNap roxen from RNaproxen with the help of NacetylLcysteine capped gold nanoparticles, i.e., NALC as chiral selector.…”

Section: Detection Of Small Moleculesmentioning

confidence: 99%

Ion Selective Nanochannels: From Critical Principles to Sensing and Biosensing Applications

Soozanipour

Sohrabi

Abazar

et al. 2021

Adv Materials Technologies

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High throughput; (D) Mold and releasing issue, hard to form deep channels Large scale channel array, 2D channel, 1D nanoslit Thin film deposition 30-200 Polysilicon, Silicon dioxide, Silicon nitride, polymer (A) simple process, low cost, fast; (D) Hard to form uniform channels large scale array, 2D channel, 1D nanoslit Hot embossing >50 PET, PC, PS, PMMA, etc. (A) Simple process, low cost; (D) Easy to deformation Large scale array, 2D channel, 1D nanoslit deformation of PDMS 100-800 PDMS (A) Simple process, low cost; (D) Low yield large scale array, V-shaped channel, 2D channel Stress release 20-800 PS, PDMS, Photoresist (A) Low cost, maskless, simple process; (D) Low resolution, Low yield large scale array, V-shaped channel, 1D nanoslit Molecular self-assembly 20-800 Ti, Silicon, Polymer, etc. (A) Low cost; (D) Complex process, Low yield 2D channel, 1D nanoslit

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Zinc ion driven ionic conduction through single asymmetric nanochannels functionalized with nanocomposites

Cited by 22 publications

References 53 publications

Electric Migration of Hydrogen Ion in Pore-Voltammetry Suppressed by Nafion Film

Electric Migration of Hydrogen Ion in Pore-Voltammetry Suppressed by Nafion Film

Ultrasensitive and Selective Protein Recognition with Nanobody‐Functionalized Synthetic Nanopores

Ion Selective Nanochannels: From Critical Principles to Sensing and Biosensing Applications

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