Zinc Ion-crosslinked polycarbonate/heparin composite coatings for biodegradable Zn-alloy stent applications

Pan, Kai; Zhang, Wei; Shi, Hua; Dai, Miao; Wei, Wei; Liu, Xiaoya; Li, Xiaojie

doi:10.1016/j.colsurfb.2022.112725

Cited by 22 publications

(8 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The slow release of Si ions from the SRL@fPCL and Zn-SRL@fPCL stents compared with that of the fPCL stents was mainly attributed to the additional PLLA coating on the fPCL stent and Zn ion implantation. The release path of Si ions should be longer because of the supplemented sirolimus containing PLLA coating, and this type of additional polymeric coating has been acknowledged to act as a barrier for the release of ions or drugs [ 39 , 97 , 98 ]. The Si ion release rate was further suppressed in the Zn-SRL@fPCL stents, which was attributed to the formation of a Zn ion-based nanolayer in the PLLA coating.…”

Section: Resultsmentioning

confidence: 99%

3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation

Lee,

Won,

Park

et al. 2024

Bioactive Materials

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation

Lee,

Won,

Park

et al. 2024

Bioactive Materials

View full text Add to dashboard Cite

“…Endothelialization occurs at a faster rate compared to bare Zn alloy. Additionally, the surface erosion of the composite coating leads to the uniform and long-term release of heparin, significantly inhibiting platelet adhesion and activation [ 126 ]. The PLGA/PDA coating improves the material's corrosion resistance, enhances in vitro biocompatibility, and inhibits hemolysis and smooth muscle cell (SMC) proliferation.…”

Section: Discussionmentioning

confidence: 99%

Structural and temporal dynamics analysis of zinc-based biomaterials: History, research hotspots and emerging trends

Yuan,

Deng,

Tan

et al. 2024

Bioactive Materials

View full text Add to dashboard Cite

“…Immersion testing was performed following protocols adapted from previous studies. ,, Briefly, each specimen was mechanically polished with SiC papers down to 1200 grit. The immersion solution was oxygenated Hank’s balanced salt solution (1× HBSS; Gibco) that had the pH adjusted to 7.4 using NaOH.…”

Section: Methodsmentioning

confidence: 99%

Effect of TiC Nanoparticles on a Zn-Al-Cu System for Biodegradable Cardiovascular Stent Applications

Zeng,

Murali,

See

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Despite being a weaker metal, zinc has become an increasingly popular candidate for biodegradable implant applications due to its suitable corrosion rate and biocompatibility. Previous studies have experimented with various alloy elements to improve the overall mechanical performance of pure Zn without compromising the corrosion performance and biocompatibility; however, the thermal stability of biodegradable Zn alloys has not been widely studied. In this study, TiC nanoparticles were introduced for the first time to a Zn-Al-Cu system. After hot rolling, TiC nanoparticles were uniformly distributed in the Zn matrix and effectively enabled phase control during solidification. The Zn−Cu phase, which was elongated and sharp in the reference alloy, became globular in the nanocomposite. The strength of the alloy, after introducing TiC nanoparticles, increased by 31% from 259.7 to 340.3 MPa, while its ductility remained high at 49.2% elongation to failure. Fatigue performance also improved greatly by adding TiC nanoparticles, increasing the fatigue limit by 47.6% from 44.7 to 66 MPa. Furthermore, TiC nanoparticles displayed excellent phase control capability during body-temperature aging. Without TiC restriction, Zn−Cu phases evolved into dendritic morphologies, and the Al-rich eutectic grew thicker at grain boundaries. However, both Zn−Cu and Al-rich eutectic phases remained relatively unchanged in shape and size in the nanocomposite. A combination of exceptional tensile properties, improved fatigue performance, better long-term stability with a suitable corrosion rate, and excellent biocompatibility makes this new Zn-Al-Cu-TiC material a promising candidate for biodegradable stents and other biodegradable applications.

show abstract

Zinc Ion-crosslinked polycarbonate/heparin composite coatings for biodegradable Zn-alloy stent applications

Cited by 22 publications

References 46 publications

3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation

3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation

Structural and temporal dynamics analysis of zinc-based biomaterials: History, research hotspots and emerging trends

Effect of TiC Nanoparticles on a Zn-Al-Cu System for Biodegradable Cardiovascular Stent Applications

Contact Info

Product

Resources

About